Results 231 to 240 of about 3,572,657 (302)

Unique tree: Foliar endophytic fungi of the critically endangered Andreadoxa flava (Rutaceae) in Brazil. [PDF]

Braz J Microbiol
Oliveira RJV, Prazeres JFSA, Medeiros ÉV, de Souza CAF, Bezerra JL, Bezerra JDP.   +5 more
europepmc   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Prevalence, diagnostic evaluation, and disease associations of vector-borne pathogens in domestic dogs across Namibia: a multi-modal approach. [PDF]

Parasit Vectors
de Villiers L, Schoeman JP, Penzhorn BL, Molini U, de Villiers M, Makgabo SM, Byaruhanga C, Collins NE, Thompson PN, Zealand S, Stoltsz WH, Baines IJM, Khaiseb S, Oosthuizen MC.   +13 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Identifications, spatial distribution, and seasonal occurrence of Culicoides in selected districts of Northwest Ethiopia. [PDF]

Sci Rep
Ayele BA, Ayele A, Molla W, Molla AB, Birhan M, Ibrahim SM, Dessalegn B, Kenubih A, Gessese AT, Kinde MZ, Dagnaw GG, Fenta MD, Mulatu T, Tesfaye H, Bitew M, Tarekegn ZS, Dejene H.   +16 more
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Multi-method approach to assessing the floral-visiting insect assemblage of rare, abophilous plant Baccharis vanessae in Southern California. [PDF]

Ecol Evol
Simokat C, Ferguson EL, Keatly J, Smith T, Lorence M, O'Hara J.   +5 more
europepmc   +1 more source

Utilization of immune checkpoint inhibitors for the treatment of cancer in Scotland, 2018–2024: A national retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of the study is to describe the use of immune checkpoint inhibitors (ICIs) for the treatment of cancer in Scotland. Methods The retrospective observational cohort study included patients aged 18 years or older who commenced treatment with an ICI in Scotland between 1 January 2018 and 31 December 2024.
Tanja Mueller, Christine Crearie, Liya Lu, Jiafeng Pan, Fraser N. Sneden, David Martin, Amanj Kurdi, Catherine S. Thomson, Julie Clarke, Marion Bennie   +9 more
wiley   +1 more source

The global determinants of climate niche breadth in birds. [PDF]

Nat Commun
Rodrigues JFM, Botero CA.
europepmc   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source