Results 131 to 140 of about 1,262,397 (358)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Equivalence of the Mediation, Confounding and Suppression Effect
Prevention Science, 2000 D. Mackinnon, J. Krull, C. Lockwood
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Approximations of standard equivalence relations and Bernoulli percolation at pu
, 2016 Damien Gaboriau, Robin Tucker-Drob
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Achievement Of Communicative Equivalency By Means Of Interlingual Mediated Communication
Polylinguality and Transcultural Practices, 2013 Miklucho-Maklay str., 6, Moscow, Russia, 117198 The article deals with the comparative analysis of cognitive-discourse factors of the mediated interlingual communication connected with national-cultural specification of the language worldview.
I A Bykova, E A Notina
doaj
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Translating Linguistic Terms: A Case Study of French and Russian Terminologies
Polylinguality and Transcultural PracticesThis paper explores the conceptual, semantic and formal features of linguistic terms that emerge in the process of selecting equivalents when translating scientific texts on linguistics from French to Russian and vice versa.
Denis S. Zolotukhin
doaj +1 more source