Results 61 to 70 of about 15,833,154 (197)

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

Advanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan, Yan Zheng, Yue Lan, Zhuo Cheng, Siya Wang, Changqing Li, Yanqiu Wang, Minghan Liu   +7 more
wiley   +1 more source

Comparison of Li-ion battery equivalent circuit modelling using impedance analyzer and Bayesian networks [PDF]

, 2018
© The Institution of Engineering and Technology 2018. An energy storage system simulation requires a battery model capable of precisely predicting the dynamic behaviour and I-V characteristics.
Gauchia, Lucia, Lucia Gauchia, Jafari, Mehdi, Khalid Khan, Khan, Khalid, Gauchía Babé, Lucía, Mehdi Jafari   +6 more
core   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

A Frequency Up-Conversion Piezoelectric Energy Harvester Shunted to a Synchronous Electric Charge Extraction Circuit

Micromachines
A frequency up-conversion piezoelectric energy harvester (FUC-PEH) consists of a force amplifier, a piezoelectric stack, a low-frequency oscillator (LFO), and a stop limiter.
Xuzhang Peng, Hao Tang, Zhongjie Li, Junrui Liang, Liuding Yu, Guobiao Hu   +5 more
doaj   +1 more source

Wearable E‐Textiles for Cardiovascular Monitoring: Materials, Devices, and Integrated Systems

Advanced Science, EarlyView.
The graphical abstract highlights the role of conductive materials and textile fabrication techniques in enabling smart textiles for cardiovascular applications. It showcases textile‐based ECG monitoring, pulse sensing, hemodynamic monitoring, and cardiovascular tissue engineering, while emphasizing the challenges and design considerations that govern ...
Bangul Khan, Mahmoud Tavakoli, Norbert Radacsi, Bee Luan KHOO   +3 more
wiley   +1 more source

LLMs as Representation Generators for Gradient‐Free Scientific Optimization: A Case Study in Battery Fast Charging

Advanced Science, EarlyView.
Large language models serve as representation generators for gradient‐free scientific optimization. Two complementary approaches produce executable battery‐charging policies either directly or through LLM‐designed neural representations coupled to Bayesian optimization.
Ge Lei, Ferran Brosa Planella, Sterling G. Baird, Samuel J. Cooper   +3 more
wiley   +1 more source

Excitation Pulse Influence on the Accuracy and Robustness of Equivalent Circuit Model Parameter Identification for Li-Ion Batteries

World Electric Vehicle Journal
An equivalent circuit model (ECM) is a highly practical tool for simulating Li-ion battery behavior. There are many relevant studies which compare different ECM variants or suggest algorithms to extract model parameters from the experimental data ...
Dmitrii K. Grebtsov, Alexey Alekseevich Druzhinin, Artem V. Sergeev   +2 more
doaj   +1 more source

State of Charge Estimation of a Lithium Ion Battery Based on Adaptive Kalman Filter Method for an Equivalent Circuit Model

Applied Sciences, 2019
Due to its accuracy, simplicity, and other advantages, the Kalman filter method is one of the common algorithms to estimate the state-of-charge (SOC) of batteries. However, this method still has its shortcomings.
Xiao Ma, Danfeng Qiu, Qing Tao, Daiyin Zhu   +3 more
doaj   +1 more source