Results 41 to 50 of about 1,260,345 (283)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Functionally graded thick-walled tubes analysis by numerical methods

Heliyon
Functionally graded materials are increasingly used in the practice of engineering design, as is the case with thick-walled tubes. The use of these constructive elements requires a calculation, which should be as accurate, as accessible and as fast as ...
Vasile Nastasescu, Silvia Marzavan
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Light enough or go lighter?

Materials & Design, 2019
A novel concept for evaluating the lightweight design of structural components, named the true lightweight degree, is developed. It is found that traditional lightweight parameters just constitute a lower bound for stiffness-oriented designs. This can be
Marlon Hahn, Soeren Gies, A. Erman Tekkaya   +2 more
doaj   +1 more source

Numerical Investigation of the Influence of Pulsed Laser Deposited Tin Thin Film Morphology on Deformation Inhomogeneities [PDF]

Archives of Metallurgy and Materials, 2020
Investigation of influence of TiN thin film morphology on deformation inhomogeneities is an overall subject of the research. Numerical modelling approach that was selected for the study is based on the digital material representation concept, which gives
K. Perzyński, D. Zych, M. Sitko, Ł. Madej   +3 more
doaj   +1 more source

Equivalent Morphology Concept in Composite Materials Using Machine Learning and Genetic Algorithm Coupling

Journal of Composites Science
The objective of this study is to investigate the synergistic integration of machine learning and evolutionary algorithms for the discovery of equivalent morphologies exhibiting analogous behavior within the domain of composite materials. To pursue this objective, two comprehensive databases are meticulously constructed.
Beji, Hamdi, Messager, Tanguy, Kanit, Toufik   +2 more
openaire   +2 more sources

Ductile Failure Prediction of U-Notched Bainitic Functionally Graded Steel Specimens Using the Equivalent Material Concept Combined with the Averaged Strain Energy Density Criterion [PDF]

Physical Mesomechanics, 2019
В статье изучено вязкое разрушение функционально-градиентной бейнитной стали. Испытания на разрушение проводили с использованием образцов с U-образным надрезом из функционально-градиентной бейнитной стали при нагружении типа I. Оценку вязкого разрушения образцов проводили с использованием критерия усредненной плотности энергии деформации и концепции ...
Salavati, Hadi, Mohammadi, Hossein
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Some remarks on materials with memory: heat conduction and viscoelasticity [PDF]

, 2005
Materials with memory are here considered. The introduction of the dependence on time not only via the present, but also, via the past time represents a way, alternative to the introduction of possible non linearities, when the physical problem under ...
Carillo, Sandra
core   +1 more source

On the combined use of averaged strain energy density criteria (ASED) and equivalent material concept (ECC) for the fracture load prediction of additively manufactured PLA v-notched specimens

Procedia Structural Integrity, 2023
The growing introduction into the industrial world of additive fused deposition technologies, for producing functional components made of thermoplastic materials (such as PLA), pushes designers to know which methods for predicting breakage under load can be used to design correctly these elements.
Morettini G., Razavi S. M. J., Staffa A., Palmieri M., Berto F., Cianetti F., Braccesi C.   +6 more
openaire   +1 more source