Results 41 to 50 of about 360,951 (247)
KKM implies the Brouwer fixed point theorem: Another proof
Results in Nonlinear Analysis, 2020 It is well-known that the Brouwer fixed point theorem (BFPT), the weak Sperner combinatorial lemma, and the Knaster-Kuratowski-Mazurkiewicz (KKM) theorem are mutually equivalent and have scores of equivalent formulations and several thousand applications.
Sehie Park
doaj
Fujita Medical Journal, 2019 Background: Although fatigue is an important nonmotor symptom in Parkinson’s Disease (PD) patients, little is known about the pathophysiological details of fatigue in PD, and it is still unknown whether fatigue correlates with PD prognosis. In this study,
Yoshiki Niimi +5 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Cartilage & Joint PreservationIntroduction: Some patients with cartilage defects of the knee are known to report similar quality of life (QoL) scores to patients listed for total knee arthroplasty.
Gwenllian F. Tawy, Michael J. McNicholas
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Jurnal Pendidikan Teknologi dan Kejuruan, 2016 This study aims at investigating the difference of creativity between the students treated with the Student-Centered Learning (SCL) strategy and the students treated with the Direct Learning strategy.
Aan Ardian, Sudji Munadi
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Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Frontiers in MedicineObjectiveThis research aimed to evaluate the pain-relieving effectiveness and practicality of various regional anesthesia approaches in individuals undergoing hepatic procedures.MethodA total of 10 randomized controlled trials involving 710 patients were
Ke Sun +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019 Introduction Culturally fair cognitive assessments sensitive to detecting changes associated with prodromal Alzheimer's disease are needed. Methods Performance of Hispanic and non‐Hispanic older adults on the Loewenstein‐Acevedo Scale of Semantic ...
Rosie E. Curiel Cid +14 more
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