Results 61 to 70 of about 360,951 (247)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Equivalence of students' scores on timed and untimed anatomy practical examinations

Anatomical Sciences Education, 2013
Untimed examinations are popular with students because there is a perception that first impressions may be incorrect, and that difficult questions require more time for reflection. In this report, we tested the hypothesis that timed anatomy practical examinations are inherently more difficult than untimed examinations.
Zhang, Guiyan, Fenderson, Bruce, Schmidt, Richard R, Veloski, J J   +3 more
openaire   +3 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Measurement equivalence of the English, Chinese and Malay versions of the World Health Organization quality of life (WHOQOL-BREF) questionnaires

Health and Quality of Life Outcomes, 2019
Background The WHOQOL-BREF is a widely used questionnaire for measuring quality of life. It is important to establish the measurement equivalence of various language versions of WHOQOL-BREF so that scores from different language versions may be pooled ...
Yin Bun Cheung, Khung Keong Yeo, Kok Joon Chong, Eric Yin Hao Khoo, Hwee Lin Wee   +4 more
doaj   +1 more source

Efficient Score-Based Learning of Equivalence Classes of Bayesian Networks [PDF]

, 2000
The use of bayesian networks for knowledge discovery requires learning algorithms which emphasize not only the predictive power but also the structural fidelity of the discovered networks. Previous work on score-based methods for learning equivalence classes of bayesian networks showed that they generally provide better results than classical ...
Paul Munteanu, Denis Cau
openaire   +1 more source

Equivalence of LD-Score Regression and Individual-Level-Data Methods [PDF]

, 2017
AbstractLD-score (LDSC) regression disentangles the contribution of polygenic signal, in terms of SNP-based heritability, and population stratification, in terms of a so-called intercept, to GWAS test statistics. Whereas LDSC regression uses summary statistics, methods like Haseman-Elston (HE) regression and genomic-relatedness-matrix (GRM) restricted ...
de Vlaming, Ronald, Johannesson, Magnus, Magnusson, Patrik K.E., Ikram, M. Arfan, Visscher, Peter M.   +4 more
openaire   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Quality of life, mental health and health beliefs in haemodialysis and peritoneal dialysis patients: Investigating differences in early and later years of current treatment

BMC Nephrology, 2008
Background The study examines differences regarding quality of life (QoL), mental health and illness beliefs between in-centre haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD/PD) patients.
Tomaras V, Synodinou C, Theofilou P, Ginieri-Coccossis M, Soldatos C   +4 more
doaj   +1 more source

Developing Middle School Students’ Computational Thinking Skills Using Unplugged Computing Activities

Informatics in Education, 2020
This study investigated the role of using unplugged computing activities on developing computational thinking (CT) skills of 6th-grade students. The unplugged computing classroom activities were based on the Bebras challenge, an international contest ...
Havva DELAL, Diler ONER
doaj   +1 more source