Results 131 to 140 of about 40,852 (216)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The role of endoplasmic reticulum in human adipose tissue [PDF]
Adipose tissue plays a central role in the regulation of metabolic homeostasis. In obesity adipocytes are challenged by many insults: surplus energy, inflammation, insulin resistance and considerable endoplasmic reticulum (ER) stress.
Alhusaini, S. (Saif)
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Avaliação da ativação da via UPR (Unfolded Protein Response) em células de indivíduos HIV positivos sob diferentes esquemas terapêuticos [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em BiotecnologiaA via UPR (do inglês Unfolded Protein Response) é uma resposta celular ao acúmulo de proteínas desenoveladas no ...
Borsa, Mariana
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, 2022 Hvordan behandler man angstsygdomme og stresstilstande?Hvis ikke man selv oplever udtalt angst eller stress, er der stor sandsynlighed for, at man er pårørende til én eller flere, der gør, for angst er en folkesygdom, og stresssymptomer er hyppigt ...
Videbech, Poul Bror Hemming +1 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice
, 2015 Bone formation and maintenance depend on the balance between bone matrix synthesis and degradation. Shift of this balance may lead to pathological conditions such as osteoporosis or hyperostosis.
Tsang, KY +9 more
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Molecular CancerTumor cells utilize various strategies to enable themselves to survive under adverse conditions and to inhibit the development of antitumor immunity. Factors in the tumor microenvironment (TME), e.g., hypoxia, oxidative stress, and nutrient deprivation ...
Yingfan Zhao +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source