Results 101 to 110 of about 276,321 (287)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Dynamical Downscaling of ERA-Interim Temperature and Precipitation for Alaska

Journal of Applied Meteorology and Climatology, 2016
AbstractThe European Centre for Medium-Range Weather Forecasts interim reanalysis (ERA-Interim) has been downscaled using a regional model covering Alaska at 20-km spatial and hourly temporal resolution for 1979–2013. Stakeholders can utilize these enhanced-resolution data to investigate climate- and weather-related phenomena in Alaska. Temperature and
Peter A. Bieniek, Uma S. Bhatt, John E. Walsh, T. Scott Rupp, Jing Zhang, Jeremy R. Krieger, Rick Lader   +6 more
openaire   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Evaluating Eight Global Reanalysis Products for Atmospheric Correction of Thermal Infrared Sensor—Application to Landsat 8 TIRS10 Data

Remote Sensing, 2018
Global reanalysis products have been widely used for correcting the atmospheric effects of thermal infrared data, but their performances have not been comprehensively evaluated.
Xiangchen Meng, Jie Cheng
doaj   +1 more source

Contiguous US summer maximum temperature and heat stress trends in CRU and NOAA Climate Division data plus comparisons to reanalyses. [PDF]

, 2018
Warming is a major climate change concern, but the impact of high maximum temperatures depends upon the air's moisture content. Trends in maximum summertime temperature, moisture, and heat index are tracked over three time periods: 1900-2011, 1950-2011 ...
Grotjahn, Richard, Huynh, Jonathan
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Improving InSAR geodesy using global atmospheric models [PDF]

, 2014
Spatial and temporal variations of pressure, temperature and water vapor content in the atmosphere introduce significant confounding delays in Interferometric Synthetic Aperture Radar (InSAR) observations of ground deformation and bias estimatesof ...
Agram, Piyush Shanker, Doin, Marie-Pierre, Jolivet, Romain, Li, Zhenhong, Lin, Nina Y., Peltzer, Gilles, Simons, Mark   +6 more
core   +4 more sources

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source