Results 61 to 70 of about 1,717,234 (291)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Notes on the correlation between sudden stratospheric warmings and solar activity [PDF]
Annales Geophysicae, 2019 A correlation between solar activity and normalized occurrence rate of sudden stratospheric warmings (SSWs) has been found. As a proxy for solar activity, the 10.7 cm solar radio flux has been used.
E. Vorobeva
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Tellus: Series A, Dynamic Meteorology and Oceanography, 2017 Atmospheric blocking events are known to locally explain a large part of climate variability. However, despite their relevance, many current climate models still struggle to represent the observed blocking statistics.
Kerstin Hartung +2 more
doaj +1 more source
, 2015 skin and sea surface temperature from ERA-Interim over Amazon ...
Juan carlos Jimenez-munoz (690806)
core +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Global IWV trends and variability in atmospheric reanalyses and GPS observations [PDF]
Atmospheric Chemistry and Physics, 2018 This study investigates the means, variability, and trends in integrated water vapour (IWV) from two modern reanalyses (ERA-Interim and MERRA-2) from 1980 to 2016 and ground-based GPS data from 1995 to 2010. It is found that the mean distributions and
A. C. Parracho +3 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source