Results 61 to 70 of about 276,321 (287)

ERA Policy Brief. Del 1.4 Interim policy recommendation

, 2022
In this policy brief, the EUTOPIA TRAIN reports on the progress made in the transformation modules and provide recommendations to the European Commission for further policy development.
openaire   +1 more source

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

New method for detecting extratropical cyclones: the eight-section slope detecting method

Atmospheric and Oceanic Science Letters, 2020
An algorithm for identifying extratropical cyclones (ECs) on the basis of gridded data is proposed in this study. The algorithm, which is named the eight-section slope detecting (ESSD) method, has five key procedures to identify an EC by using the mean ...
Lizhi JIANG, Shenming FU, Jianhua SUN
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Atmospheric parameters in a subtropical cloud regime transition derived by AIRS and MODIS: observed statistical variability compared to ERA-Interim [PDF]

, 2014
Cloud occurrence, microphysical and optical properties, and atmospheric profiles within a subtropical cloud regime transition in the northeastern Pacific Ocean are obtained from a synergistic combination of the Atmospheric Infrared Sounder (AIRS) and the
B. H. Kahn, J. Karlsson, K. Sušelj, M. M. Schreier, Q. Yue, S. C. Ou, S. L. Nasiri   +6 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evaluation of four global reanalysis products using in-situ observations in the Amundsen Sea Embayment, Antarctica [PDF]

, 2016
The glaciers within the Amundsen Sea Embayment (ASE), West Antarctica, are amongst the most rapidly retreating in Antarctica. Meteorological reanalysis products are widely used to help understand and simulate the processes causing this retreat.
Holland, D.M., Jones, R.W., Lazzara, M.A., Orr, A., Renfrew, I.A., Webber, B.G.M.   +5 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Wind and Wave Extremes over the World Oceans from Very Large Ensembles [PDF]

, 2014
Global return values of marine wind speed and significant wave height are estimated from very large aggregates of archived ensemble forecasts at +240-h lead time.
Aarnes, Bidlot, Breivik, Breivik, Buizza, Caires, Coles, Compo, Debernard, Dee, Elsner, Hagedorn, Hemer, Hersbach, Izaguirre, Izaguirre, Janssen, Jean-Raymond Bidlot, Kalnay, Kharin, Lopatoukhin, Magnusson, Magnusson, Molteni, Ole Johan Aarnes, Onogi, Oouchi, Peter A.E.M. Janssen, Reistad, Rienecker, Saha, Saleh Abdalla, Stockdale, Uppala, Vinoth, Vitart, Wang, Wang, Wang, Wang, Weisse, World Meteorological Organization, Young, Øyvind Breivik   +43 more
core   +2 more sources