Results 181 to 190 of about 233,296 (308)

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Real-World Observational Clinical Study Assessing the Effectiveness and Safety of Vonoprazan-Based Dual Therapy Versus Proton Pump Inhibitor-Based Triple Therapy for <i>Helicobacter pylori</i> Eradication. [PDF]

Gastroenterology Res
Bandyopadhyay S, Panchal G, Khalse M, Patel K.   +3 more
europepmc   +1 more source

Winners and losers from Johne’s disease eradication from the Scottish dairy herd: a Markov-Chain simulation

In this paper, we evaluated the welfare effects of a hypothetical programme of Johne's disease eradication from the Scottish dairy herd on different stakeholders in the domestic milk market. We undertook the evaluation using a Markov-Chain simulation and
Weldegebriel, Habtu T., Gunn, George J., Stott, Alistair W.   +2 more
core   +1 more source

Global Polio Eradication progress 1999 [PDF]

The global initiative to eradicate polio by the end of 2000 has become the largest public health initiative in history, and is spearheaded by WHO, Rotary International, U.S. Centers for Disease Control and Prevention, and UNICEF.

core  

Engineered Au@CeO2 Hybrid Nanoparticles With Microenvironment Dependent Self‐Adjustability for Integration of Tumor‐Specific Photothermal‐Chemodynamic Therapy and Inflammation Prevention

Advanced Science, EarlyView.
An intelligent Au@CeO2 Hybrid Nanoparticles (ACEF) with microenvironment‐dependent self‐adjustability was engineered to not only perform efficient and tumor‐specific photothermal‐chemodynamic therapy for precise tumor elimination, but also serve as a ROS scavenger in healthy tissues around the tumor to avoid the unexpected oxidative damage and ...
Wenyun Mu, Wenjuan Tang, Handan Zhang, Jie Liu, Jiaqi Zhang, Yu Yao, Xiao Fu, Xin Chen, Yanmin Zhang   +8 more
wiley   +1 more source

Preliminary research on the effectiveness and safety of metal clip-assisted endoscopic variceal ligation in the treatment of gastric varices. [PDF]

Ther Adv Gastroenterol
Yi W, Xiuling L, Hui D, Zhenjuan L, Jiaxin L, Runzhao Q.   +5 more
europepmc   +1 more source

The Aedes aegypti Eradication Program [PDF]

Introduction -- History -- -- How the program works -- Organization -- Field operations -- Working with the community -- -- The program thus far -- Special problems -- Research.Two years ago the Public Health Service began a program to eradicate Aedes ...

core  

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Helicobacter pylori eradication – an update on the latest therapies

, 2014
Background The eradication of Helicobacter pylori (H. pylori) can be challenging in certain circumstances. There is no current first-line therapy that is curative in all patients.
Yaxley, Julian, Chakravarty, Bhaskar
core  

Light‐Activated Ruthenium Nanoclusters Reprogram the Metabolic‐Quorum Sensing Axis for Precision Periodontitis Therapy

Advanced Science, EarlyView.
Under 660 nm visible light, Ru NCs efficiently photocatalyze nitrate‐to‐ammonium conversion and modulate oral nitrogen metabolism. They precisely perturb Veillonella parvula, block its key support to Porphyromonas gingivalis, and exert an “inhibiting without killing” antivirulence effect.
Jing Zhou, Xiaolin Sun, Chengyu Liu, Yujia Shi, Meiqi Li, Meng Bo, Jingjie Zhai, Chunyan Li, Zhennan Wu, Xue Bai, Lin Wang   +10 more
wiley   +1 more source