Results 31 to 40 of about 173,917 (262)

Epidemiology and genetic characterization of orphan polioviruses in Africa, 2022–2024: Unmasking silent transmission and implications for eradication

Vaccine: X
Background: The continued detection of orphan polioviruses, defined by ≥ 1.5 % nucleotide divergence in the VP1-coding region of the virus compared with the VP1 of previous circulating isolates, presents a significant challenge to polio eradication ...
Brook Tesfaye, Julius E. Chia, Terna Nomhwange, D. Collins Owuor, Ticha Johnson Muluh, Safdar Nosheen, Arthur Yannick Doungmo Wakem, Abdullateef Jimoh, Akif Saatcioglu, Kebba Touray, Abdulahi Walla Hamisu, Modjirom Ndoutabe, Jamal A. Ahmed, Anfumbom Kfutwah   +13 more
doaj   +1 more source

Present Status of Malaria in Nepal

Journal of Nepal Medical Association, 2003
NA
G M Sakya
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Visualization of the Evolution and Transmission of Circulating Vaccine-Derived Poliovirus (cVDPV) Outbreaks in the African Region

Bio-Protocol
Since the creation of the Global Polio Eradication Initiative (GPEI) in 1988, significant progress has been made toward attaining a poliovirus-free world. This has resulted in the eradication of wild poliovirus (WPV) serotypes two (WPV2) and three (WPV3)
D. Owuor, Brook Tesfaye, Arthur Wakem, Sakma Kabore, Caroline Ikeonu, Mariette Doussoh, Priscilla Sigala, Idris Ibrahim, Abdullateef Jimoh, Idah Ndumba, Jermaine Khumalo, David Oviaesu, Cheroigin Kipchirchir, Carolyne Gathenji, John Kipterer, Kebba Touray, Hamisu Abdullahi, Kathleen Rankin, Ousmane Diop, Julius Chia, Ndoutabe Modjirom, Jamal Ahmed, Anfumbom Kfutwah   +22 more
doaj   +1 more source

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

Identification of Potential Vectors and Species Density of Tsetse Fly, Prevalence, and Genetic Diversity of Drug-Resistant Trypanosomes in Kenya

Pathogens
Tsetse flies are major vectors of trypanosomes in Sub-Saharan Africa, posing risks to livestock and human health. This study investigated the diversity, distribution, and infection rates of tsetse species, as well as the genetic diversity of drug ...
Ivy S. Okello, Samuel G. Onyoyo, Isaiah N. Kiteto, Sylvia M. Korir, Seth. O. Onyango   +4 more
doaj   +1 more source

One‐Step Curcumin‐Mediated Multiphoton Lithography for Bioactive 3D Scaffolds

Advanced Functional Materials, EarlyView.
Curcumin‐mediated multiphoton lithography enables one‐step fabrication of highly architected complex gelatin methacryloyl scaffolds by exploiting curcumin as a multifunctional bioactive photoinitiator. The resulting 3D structures support mesenchymal stem cell adhesion, proliferation, and migration, while exhibiting dual antibacterial activity through ...
Myrto Charitaki, Michalis Stavrou, Chrysanthi Pinelopi Apostolidou, Elmina Kabouraki, David Gray, Anna Mitraki, Anthi Ranella, Maria Farsari   +7 more
wiley   +1 more source

Dynamically Actuated Reconfigurable Topographical Surface Enables Active Control of Implant‐Associated Infections

Advanced Functional Materials, EarlyView.
A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash, Jihun Lee, J. Scott VanEpps, Sungmin Nam, Jouha Min   +4 more
wiley   +1 more source

Eradicating polio [PDF]

Science, 2015
On 20 September 2015, the Global Commission for the Certification of Poliomyelitis Eradication (GCC) declared that type 2 wild poliovirus had been eradicated. The GCC examined reports from 189 of 195 countries around the world and studied separate data [held by the World Health Organization (WHO)] from the remaining countries.
Anthony, Adams, David M, Salisbury
openaire   +2 more sources

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source