Results 31 to 40 of about 103,457 (262)

Poliovirus excretion among children with primary immune deficiency in Pakistan: a pilot surveillance study protocol

BMJ Open, 2021
Introduction Children with primary immunodeficiency disorders (PID) are more susceptible to developing viral infections and are at a substantially increased risk of developing paralytic poliomyelitis.
Ali Faisal Saleem, Asma Sadruddin Pethani, Zaubina Kazi, Ujala Nayyar, Muhammad Shafiq-ur-Rehman, Muhammad Tahir Yousafzai, Mach Ondrej   +6 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

vineyk24/Island-Eradication: Island Eradication Release

, 2022
This is the release of the island eradication repository for creating a permanent ...
vineyk24
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Polio transition in the African Region: progress, challenges and prospects for health systems integration

BMC Infectious Diseases
Background The Global Polio Eradication Initiative (GPEI) has made substantial progress towards global eradication of polio. As regions, including Africa, approach the final stages of this goal, countries must ensure that essential polio functions are ...
Terna Nomhwange, Samafilan Ainan, Modjirom Nduotabe, Usman Adamu, Ogonna Chinwike, Kennedy Adejoh, Sule Adamu, Christopher Kamugisha, Ticha Johnson, Casimir Manengu, Gedi Mohamed   +10 more
doaj   +1 more source

Epidemiology and genetic characterization of orphan polioviruses in Africa, 2022–2024: Unmasking silent transmission and implications for eradication

Vaccine: X
Background: The continued detection of orphan polioviruses, defined by ≥ 1.5 % nucleotide divergence in the VP1-coding region of the virus compared with the VP1 of previous circulating isolates, presents a significant challenge to polio eradication ...
Brook Tesfaye, Julius E. Chia, Terna Nomhwange, D. Collins Owuor, Ticha Johnson Muluh, Safdar Nosheen, Arthur Yannick Doungmo Wakem, Abdullateef Jimoh, Akif Saatcioglu, Kebba Touray, Abdulahi Walla Hamisu, Modjirom Ndoutabe, Jamal A. Ahmed, Anfumbom Kfutwah   +13 more
doaj   +1 more source

Present Status of Malaria in Nepal

Journal of Nepal Medical Association, 2003
NA
G M Sakya
doaj   +1 more source

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

Visualization of the Evolution and Transmission of Circulating Vaccine-Derived Poliovirus (cVDPV) Outbreaks in the African Region

Bio-Protocol
Since the creation of the Global Polio Eradication Initiative (GPEI) in 1988, significant progress has been made toward attaining a poliovirus-free world. This has resulted in the eradication of wild poliovirus (WPV) serotypes two (WPV2) and three (WPV3)
D. Owuor, Brook Tesfaye, Arthur Wakem, Sakma Kabore, Caroline Ikeonu, Mariette Doussoh, Priscilla Sigala, Idris Ibrahim, Abdullateef Jimoh, Idah Ndumba, Jermaine Khumalo, David Oviaesu, Cheroigin Kipchirchir, Carolyne Gathenji, John Kipterer, Kebba Touray, Hamisu Abdullahi, Kathleen Rankin, Ousmane Diop, Julius Chia, Ndoutabe Modjirom, Jamal Ahmed, Anfumbom Kfutwah   +22 more
doaj   +1 more source

One‐Step Curcumin‐Mediated Multiphoton Lithography for Bioactive 3D Scaffolds

Advanced Functional Materials, EarlyView.
Curcumin‐mediated multiphoton lithography enables one‐step fabrication of highly architected complex gelatin methacryloyl scaffolds by exploiting curcumin as a multifunctional bioactive photoinitiator. The resulting 3D structures support mesenchymal stem cell adhesion, proliferation, and migration, while exhibiting dual antibacterial activity through ...
Myrto Charitaki, Michalis Stavrou, Chrysanthi Pinelopi Apostolidou, Elmina Kabouraki, David Gray, Anna Mitraki, Anthi Ranella, Maria Farsari   +7 more
wiley   +1 more source