Results 101 to 110 of about 103,457 (262)
Advanced Science, EarlyView.A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan +10 more
wiley +1 more source
Inactivated Poliovirus Vaccine: Recent Developments and the Tortuous Path to Global Acceptance
PathogensInactivated poliovirus vaccine (IPV), available since 1955, became the first vaccine to be used to protect against poliomyelitis. While the immunogenicity of IPV to prevent paralytic poliomyelitis continues to be irrefutable, its requirement for strong ...
Roland W. Sutter +4 more
doaj +1 more source
Advanced Science, EarlyView.Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su +7 more
wiley +1 more source
Global Polio Eradication Initiative
Presentations February 2017 Day 1On the agenda, this presentation listed as: Global Polio Eradication Initiative.Slides from a presentation at the Advisory Committee on Immunization Practices meeting February 22-23, 2017, Atlanta, GA.global-01-anand ...
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Global polio eradication : reaching every last child [PDF]
Polio is a crippling and potentially deadly infectious disease. The virus spreads from person to person and can invade an infected person\u2019s spinal cord, causing life-long paralysis or in rare instances, death.
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Advanced Science, EarlyView.A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li +13 more
wiley +1 more source
Global Polio Eradication Initiative; strategic plan, 2001-2005
Extraordinary progress has been made toward global eradication of poliomyelitis. Only 30 countries were considered endemic at the end of 1999, down from 50 in 1998.
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Advanced Science, EarlyView.Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin +13 more
wiley +1 more source
Global Polio Eradication progress 2000
The Global Polio Eradication Initiative, the largest public health initiative in history, is on track to certify the world polio-free in 2005. Polio cases have declined by 99% since the launch of the Initiative in 1988, from 350 000 to less than 3500 ...
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Advanced Science, EarlyView.ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng +6 more
wiley +1 more source