Results 241 to 250 of about 516,154 (332)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Colistin-based combination therapy versus monotherapy for carbapenem-resistant gram-negative bacterial infections: a systematic review and meta-analysis. [PDF]

Front Cell Infect Microbiol
Yang T, Li H, Xu X, An J, Zhang Z, Li B, Dou Z.   +6 more
europepmc   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Efficacy of fourteen-day once-daily vonoprazan-based quadruple therapy for Helicobacter pylori in high clarithromycin-resistance regions (ONCE-VONO Trial). [PDF]

Sci Rep
Sukkamolsantiporn S, Bongkotvirawan P, Chonprasertsuk S, Pornthisarn B, Siramolpiwat S, Bhanthumkomol P, Issariyakulkarn N, Gamnarai P, Wongcha-Um A, Aumpan N, Vilaichone V, Sornchuer P, Mahachai V, Miftahussurur M, Yamaoka Y, Kitipawong P, Vilaichone RK.   +16 more
europepmc   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

<i>Helicobacter pylori</i> Eradication: Why Recurrence Risk Should Not Dictate Treatment Decisions. [PDF]

Ther Clin Risk Manag
Chen X, Wang Y, Dong Y, Yang J, Xie B, Zhang D.   +5 more
europepmc   +1 more source

799 ASSESSMENT OF THE DEVELOPMENT OF HEPATOCELLULAR CARCINOMA IN HEPATITIS C VIRUS ERADICATED PATIENTS AFTER INTERFERON THERAPY

, 2009
Shinsuke Kira, Shiomi Aimitsu, Yasuyuki Aisaka, Kazuya Iwamoto, Hiroyoshi DOHI   +4 more
openalex   +1 more source

Exploring the Vasculitis‐Tumors Link: Epidemiological Patterns, Mechanistic Insights, and Clinical Implications

Advanced Science, EarlyView.
This review outlines association between vasculitis and malignancies and provides practical value for clinicians in distinguishing primary vasculitis from malignancy‐associated forms and optimizing patient surveillance, improving recognition of tumor‐associated vasculitis to reduce the risk of misdiagnosis, supporting more accurate clinical decision ...
Xiaofei Shi, Zhijiao Li, Xin Ma, Bei Zhang, Xinfeng Wu, Hua Fan, Rongzeng Liu, Hongwei Jiang, Cong‐Qiu Chu   +8 more
wiley   +1 more source

Rebamipide as an Adjunctive Therapy for Gastrointestinal Diseases: An Umbrella Review. [PDF]

Pharmaceuticals (Basel)
Maev IV, Khurmatullina AR, Andreev DN, Zaborovsky AV, Kucheryavyy YA, Sokolov PS, Beliy PA.   +6 more
europepmc   +1 more source

Inadequacy of Micro-Finance for Eradicating Rural poverty in Andhra Pradesh: Trends in Perspective

, 2011
Paritosh Sharma
openalex   +1 more source