Results 241 to 250 of about 95,906 (268)

Expression of ErbB-1 and ErbB-2 in meningioma

Journal of Clinical Neuroscience, 2010
Meningiomas are benign intracranial tumours treated by neurosurgical resection. Residual or recurrent tumour may be treated with radiotherapy. Effective molecular therapy for residual and recurrent meningiomas is currently unavailable. We tested meningiomas for In-ErbB-1 and ErbB-2, and the levels were compared to normal brain, peripheral nerve ...
Agadha, Wickremesekera, Christopher M, Hovens, Andrew H, Kaye   +2 more
openaire   +2 more sources

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

Experimental Cell Research, 2003
ErbB-2 (also called HER2/neu) and ErbB-3 are closely related to the epidermal growth factor receptor (EGFR/ErbB-1), but unlike EGFR, ErbB-2 is a ligandless receptor, whereas ErbB-3 lacks tyrosine kinase activity. Hence, both ErbB-2 and ErbB-3 are active only in the context of ErbB heterodimers, and ErbB-2.
Ami, Citri, Kochupurakkal Bose, Skaria, Yosef, Yarden   +2 more
openaire   +2 more sources

ErbBs in lung cancer

Experimental Cell Research, 2009
Lung cancer remains the leading cause of cancer deaths worldwide, and advanced stage disease is largely refractory to conventional chemotherapy. Thus, there is an important need for alternative treatment strategies, and the ErbB proteins have emerged as potentially important therapeutic drug targets in this setting, apparently reflecting a state of ...
Sreenath V, Sharma, Jeffrey, Settleman
openaire   +2 more sources

Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines

Cancer Immunology, Immunotherapy, 2002
The tumour antigen ErbB-2 belongs to the epidermal growth factor receptor family. Numerous studies have shown that ErbB-2 is overexpressed in many cancers and it is prognostically important in a subset of malignancies. It is well recognised that this receptor has many characteristics that make it an excellent target for tumour-specific immunotherapy ...
Yip, Yum L., Ward, Robyn L.
openaire   +3 more sources

ErbB‐3 and ErbB‐4 Expression in the Mouse Olfactory System^a

Annals of the New York Academy of Sciences, 1998
ABSTRACT: The interplay between neuregulins and the ErbB receptor family has a pivotal role in the development of several tissues, including the nervous system, and is maintained in the adult olfactory system where extensive plasticity and neurogenesis are retained.
PERROTEAU, Isabelle, OBERTO M, IERACI A, BOVOLIN, Patrizia, FASOLO, Aldo   +4 more
openaire   +3 more sources

ErbBs in mammary development

Experimental Cell Research, 2003
Members of the ErbB (epidermal growth factor receptor) family of receptor tyrosine kinases are important in etiology of human mammary carcinoma, and are rational targets for cancer therapy. The frequent selection of ErbB2/HER2/Neu, and, less often, the epidermal growth factor receptor, and ErbB3 for overexpression in breast cancer implies that these ...
openaire   +2 more sources

Dominance of ErbB-1 Heterodimers in Lung Epithelial Cells Overexpressing ErbB-2

American Journal of Respiratory Cell and Molecular Biology, 1999
This article examines differential expression and heterodimer formation of ErbB family members in tumorigenic and nontumorigenic human bronchial epithelial cells (HBECs). This cell system was developed previously as a model for lung adenocarcinoma by overexpression of c-erbB-2 in nontumorigenic, T antigen-immortalized HBECs.
A M, Fernandes, A W, Hamburger, B I, Gerwin   +2 more
openaire   +2 more sources

Roles of ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland

Journal of Mammary Gland Biology and Neoplasia, 1997
ErbB-3 and ErbB-4 are the most recently discovered and least characterized of the class I tyrosine kinase receptors. ErbB-3 is noteworthy for its low tyrosine kinase activity, suggesting that it may function more as an adaptor in signaling than as a kinase. Heregulin serves as a ligand for both receptors.
K L, Carraway, C A, Carraway, K L, Carraway   +2 more
openaire   +2 more sources

ErbB Signaling

Science Signaling, 2000
Olayioye et al . have written a review on the ErbB receptors and their ligands. The review covers how receptor homo- and heterodimerization contribute to signaling complexity and specificity.
openaire   +2 more sources

Targeting ErbB receptor signaling: A pan-ErbB approach to cancer

Molecular Cancer Therapeutics, 2004
Abstract The ErbB receptors are localized to the cell membrane where they are activated by ligand to trigger a network of signaling pathways. In some cancer cells, dysregulation of ErbB-mediated signaling confers a growth advantage, resulting in cellular transformation and increased metastatic potential.
openaire   +2 more sources