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Untangling the ErbB signalling network
Nature Reviews Molecular Cell Biology, 2001When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over ...
Y, Yarden, M X, Sliwkowski
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2017
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
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The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
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ErbB Targeted Drugs and Angiogenesis
Current Vascular Pharmacology, 2010Members of the ErbB receptor tyrosine kinase family are central regulators of several normal as well as tumor cell functions. A number of therapeutic compounds such as small molecular weight tyrosine kinase inhibitors and monoclonal antibodies have been developed to inhibit ErbB signaling in cancer.
Erika, Iivanainen, Klaus, Elenius
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ErbB receptors and their ligands in the breast
Expert Reviews in Molecular Medicine, 2006ErbB receptor tyrosine kinases are membrane-bound receptors that possess intrinsic, ligand-activated, tyrosine kinase activity. Binding of growth factors to these receptors induces the formation of ErbB homo- and heterodimers and initiates a signalling cascade that traverses the cytoplasm to communicate with the nucleus and the cytoskeleton. The effect
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Science Signaling, 2003
The ErbB family of receptor tyrosine kinases, which mediates the response to epidermal growth factor (EGF) and related peptides, contains four members: the EGF receptor (EGFR, ErbB1), ErbB2, ErbB3, and ErbB4. EGFR, ErbB3, and ErbB4 undergo ligand-dependent homo- or heterodimerization, which, together with their sensitivity to multiple ...
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The ErbB family of receptor tyrosine kinases, which mediates the response to epidermal growth factor (EGF) and related peptides, contains four members: the EGF receptor (EGFR, ErbB1), ErbB2, ErbB3, and ErbB4. EGFR, ErbB3, and ErbB4 undergo ligand-dependent homo- or heterodimerization, which, together with their sensitivity to multiple ...
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Targeting ERBB Receptors in Cancer
2007Tyrosine kinases are a large and diverse family of proteins found only in metazoans. The ERBB family, which encompasses subgroup I of the receptor tyrosine kinase (RTK) superfamily, has four members: epidermal growth factor receptor (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4.
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