Results 241 to 250 of about 60,784 (262)

Targeting ERBB Receptors in Cancer

2007
Tyrosine kinases are a large and diverse family of proteins found only in metazoans. The ERBB family, which encompasses subgroup I of the receptor tyrosine kinase (RTK) superfamily, has four members: epidermal growth factor receptor (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4.
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Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

Biochemistry, 1990
The erbB-1 and erbB-2 protooncogenes encode homologous membrane receptors that respectively bind epidermal growth factor (EGF) and a still incompletely characterized ligand. Binding of EGF to its receptor is known to increase tyrosine phosphorylation of the erbB-2/neu receptor in tumor cells. To investigate the mechanism of this transregulatory pathway,
R, Goldman, R B, Levy, E, Peles, Y, Yarden   +3 more
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Expression of the ErbB Family of Receptors in Ovarian Cancer

Journal of the Society for Gynecologic Investigation, 1998
To characterize the relative levels of the ErbB family of receptors and their relationship to one another in ovarian cancer.A total of 17 serous cystadenocarcinomas were analyzed for epidermal growth factor receptor (EGF-R or ErbB-1) and ErbB-2, ErbB-3, and ErbB-4 receptor expression by Western blot analysis.
B, Scoccia, Y M, Lee, C, Niederberger, J V, Ilekis   +3 more
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ErbB receptors and the development of the nervous system

Experimental Cell Research, 2009
Tyrosine kinase receptors and their ligands allow communication between cells in the developing and adult organism. An extensive line of research has revealed that 'neuregulins', a family of EGF-like factors that signal via ErbB receptors, are used frequently for cell communication during nervous system development, and control a spectacular spectrum ...
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Neuregulins and ErbB receptors in cultured neonatal astrocytes

Journal of Neuroscience Research, 1999
Neuregulins (NRGs) are a family of growth factors involved in signaling between neurons and glial cells of the peripheral and central nervous system. NRGs are synthesized and secreted by a number of cell types including Schwann cells, neurons, and oligodendrocytes.
A, Francis, T D, Raabe, D, Wen, G H, DeVries   +3 more
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Cytohesins are cytoplasmic ErbB receptor activators.

Cell, 2010
Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors.
Bill, A., Schmitz, A., Albertoni, B., Song, J., Heukamp, L., Walrafen, D., Thorwirth, F., Verveer, P., Zimmer, S., Meffert, L., Schreiber, A., Chatterjee, S., Thomas, R., Ullrich, R., Lang, T., Famulok, M.   +15 more
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Neu/ErbB-2 Receptor

1995
Abstract The rodent 185 kD glycoprotein consists of 1260 amino acids (Bargmann et a/. 1986) (GenBank accession number X03662), whereas the human protein is 1255 amino acids long (Coussens eta/. 1985; Yamamoto et al. 1986) (GenBank accession number M11730).
Y Yarden, R B Levy
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ERBB receptors and cancer: the complexity of targeted inhibitors

Nature Reviews Cancer, 2005
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression.
Nancy E, Hynes, Heidi A, Lane
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The status and role of ErbB receptors in human cancer

Experimental and Molecular Pathology, 2008
Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands,
I, Uberall, Z, Kolár, R, Trojanec, J, Berkovcová, M, Hajdúch   +4 more
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Localization and modulation of ErbB receptor tyrosine kinases

Current Opinion in Cell Biology, 2001
The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling.
K L, Carraway, C, Sweeney
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