Results 231 to 240 of about 1,071,243 (268)

Synthesis of Large‐ and Medium‐Sized Heterobiaryl Atropisomeric Rings and Atropopeptides by Catalytic Intramolecular SNAr

Angewandte Chemie, EarlyView.
Catalytic, intramolecular N‐heterocycle arylation by nucleophilic aromatic substitution (SNAr) is now available for synthesis of highly strained macrocycles and medium‐sized heterobiaryl atropisomeric rings, including atropopeptides. Key to the approach is the ability to generate a strong base catalytically, taking advantage of base‐embedding ...
Alireza Abbasi Kejani, Paritosh Dey, Nicholas H. Stillman, Daniel M. Andrade, Michal Šimek, Martin Dračínský, Daniel Bím, Paulo H. S. Paioti   +7 more
wiley   +1 more source

The Bethesda ERCP Skills Assessment Tool (BESAT) can reliably differentiate endoscopists of different experience levels

Endoscopy International Open
Kevin Liu, B. Joseph Elmunzer, Sachin Wani, Tiffany Taft, Catharine M Walsh, Mustafa A Arain, Tyler M. Berzin, James Buxbaum, Christopher DiMaio, Syed M. Abbas Fehmi, Neil Gupta, Sreenivasa Jonnalagadda, Vladimir Kushnir, John T. Maple, Raman Muthusamy, Amit Rastogi, Janak N Shah, Amitabh Chak, Ashley Faulx, Nauzer Forbes, Rajesh N Keswani   +20 more
doaj   +1 more source

Information-seeking behaviours, attitudes and practices on sexual and reproductive health among healthcare providers in Pakistan. [PDF]

BMJ Public Health
Qureshi F, Malik SAR, Fatimi AS, Raza MA, Fatima SK, Raja S, Mohmand AK, Sarfraz M, Shahzad A, Farooq AR, Chaipiwala MM, Ali R, Heman N, Khan S, Nafees AA.   +14 more
europepmc   +1 more source

From Berzelius to Hyperspace: Previously Unrecognized Network of Reactivity in Textbook Brominations

Angewandte Chemie, EarlyView.
Robotic scans across multidimensional condition spaces of classic bromination reactions uncover regions of previously unrecognized reactivity, yielding new major products and novel substitution patterns. Correlation and anticorrelation analyses of product distributions across these hyperspaces enable reconstruction of the underlying mechanistic ...
Yankai Jia, Wai‐Shing Wong, Yasemin Bilgi‐Gadina, Louis P. J.‐L. Gadina, King‐Lam Kwong, Yanqiu Jiang, Nikolaos Vagkidis, Benito Marazzi, Peter R. Schreiner, Bartosz A. Grzybowski   +9 more
wiley   +1 more source

On-site ERCP availability and cholangitis outcomes: Retrospective cohort study

Endoscopy International Open
Rishad Khan, Kayley-Jasmin Marchena-Romero, Marwa F. Ismail, Surain B. Roberts, Nikko Gimpaya, Michael A. Scaffidi, Nasruddin Sabrie, Kareem Khalaf, Jeffrey Mosko, Paul James, Nauzer Forbes, Fahad Razak, Amol A. Verma, Samir C. Grover   +13 more
doaj   +1 more source

Healthcare systems' readiness to address gender-based violence during COVID-19 and beyond in Pakistan: a mixed methods study. [PDF]

Reprod Health
Karmaliani R, Lakhani A, Ladak L, Baig M, Parpio Y, Somani S, Camacho GG, Seuc A, Ali M.   +8 more
europepmc   +1 more source

Pathway Complexity Defines the Shape of Nucleic Acid‐Loaded Polyion Complex Micelles: Spheroids vs. Hexagonal Disks

Angewandte Chemie, EarlyView.
Same building blocks, different destinies. Pathway complexity directs nucleic acid–loaded polyion complex micelles along distinct assembly trajectories, resulting in either hexagonally shaped or spheroidal nanoparticles with distinct internal structuring.
Lennart van den Hoven, Neshat Moslehi, Eline F. Brink, Austin Hubley, Ilja K. Voets, Tina Vermonden, Elham Mirzahossein, Bas G. P. van Ravensteijn   +7 more
wiley   +1 more source

A Multifaceted Vision of Challenges and Opportunities in Practical Artificial Photosynthesis Devices. [PDF]

Artif Photosynth
Perathoner S, Li C, Wang J, Li R, Wang W, Centi G, Romano V.   +6 more
europepmc   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +1 more source