Results 141 to 150 of about 56,541 (297)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Tadalafil once daily in the management of erectile dysfunction: patient and partner perspectives

, 2009
Pierre Costa1, Thierry Grivel2, Naji Gehchan31Service d’Urologie–Andrologie, Hôpital Caremeau, Nîmes, France; 2159, Avenue Sainte-Marguerite, Nice, France; 3Eli Lilly and Company, Lilly France – Medical ...
Pierre Costa, Naji Gehchan, Thierry Grivel   +2 more
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Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Global Prevalence of Sexual Dysfunction in Individuals With Atopic Dermatitis and Asthma: A Systematic Review and Meta‐Analysis

Clinical &Experimental Allergy, EarlyView.
Sexual dysfunction is an often‐overlooked aspect of allergic diseases. It was more frequently reported in asthma than in atopic dermatitis and was consistently higher among females. Estimates varied by assessment approach, highlighting the need to address sexual health and standardise evaluation methods.
Suh Hyun Kim, Soeun Kim, Dongjin Yeo, Seohyun Hong, Yoon Lee, Yeona Jo, Seong H. Cho, Dong Keon Yon, Nikolaos G. Papadopoulos   +8 more
wiley   +1 more source

Avaliação do perfil e resultados terapêuticos de pacientes portadoes da doença de peyronie. [PDF]

, 1998
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Departamento de Clínica Cirúrgica, Curso de Medicina, Florianópolis ...
Corradi, Luciano Tozzo
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Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma

Clinical Endocrinology, EarlyView.
ABSTRACT Objective The effect of transsphenoidal surgery (TSS) on the hypothalamic‐pituitary‐gonadal (HPG) axis in patients with non‐functioning pituitary adenomas (NFPA) is underexplored, especially in women. Our aim was to investigate the HPG axis function before and after TSS, its association with quality of life (QoL), and to identify factors that ...
Victor Hantelius, Gudmundur Johannsson, Sofie Jakobsson, Erik Thurin, Tobias Hallen, Thomas Skoglund, Oskar Ragnarsson   +6 more
wiley   +1 more source

The Effect of Cervical and Lumbar Decompression Surgery for Spinal Stenosis on Erectile Dysfunction

Global Spine Journal
Study design Observational study. Objectives To evaluate the prevalence of erectile dysfunction and evaluate the effects of decompressive surgery on erectile dysfunction in cervical spinal stenosis and lumbar canal stenosis patients.
Stephanie Wottrich, Stephanie Kha, Nicolas Thompson, Dara Bakar, Philina Yee, Albert Melillo, Christopher Nash, Andrew T. Healy, Michael Steinmetz, Thomas Mroz   +9 more
doaj   +1 more source

‘We Teach Kids About It So They Don't Get Addicted’: Gender, Porn and Sex Education in New Zealand

Children &Society, EarlyView.
ABSTRACT This research sought to explore young people's and teachers' understandings of porn. Drawing on a qualitative content analysis of small focus group interview data with 106 young people aged 12–16 years old and semi‐structured interviews with six teachers in Aotearoa, New Zealand, I examine their perceptions of porn and the place of porn in sex
Claire Meehan
wiley   +1 more source

[Erectile dysfunction and obesity].

Terapevticheskii arkhiv, 2013
The review considers the relationship between obesity and erectile dysfunction (ED). Obesity is associated with the high prevalence of ED; however, the pathophysiological link between these conditions has yet to be adequately investigated. Visceral obesity leads to the enhanced activity of inflammatory responses and, thus, endothelial dysfunction and ...
A S Ametov, M V Stel'makh
openaire   +2 more sources

Pharmacological strategies for the therapy of erectile dysfunction

, 2012
Erectile dysfunction increases with aging and affects millions of men around the world. Vascular, hormonal and neurogenic factors are frequent causes of erectile dysfunction.
ARGIOLAS, ANTONIO, MELIS, MARIA ROSARIA
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