Results 51 to 60 of about 737,883 (291)

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Evaluation of the relationship between erectile dysfunction and epicardial fat tissue thickness and carotid intima-media thickness in patients with newly diagnosed hypertension

Türk Kardiyoloji Derneği Arşivi, 2020
Objective: This study is an investigation of the relationship between erectile dysfunction and epicardial adipose tissue and carotid intima-media thickness, which are indicators of endothelial dysfunction and subclinical atherosclerosis, in patients with
Davut Karakurt, Hüseyin Ede, Yasar Turan, Abdullah Gürel, İsa Ardahanlı, Taner Sarak   +5 more
doaj   +1 more source

New insights into hypertension-associated erectile dysfunction [PDF]

, 2012
Purpose of review Erectile dysfunction is recognized as a quality-of-life disorder that needs to be treated. Currently, it is estimated to affect as many as 30 million American men. Thirty percent of hypertensive patients complain of erectile dysfunction.
Webb, R. Clinton, Nunes, Kenia Pedrosa, Labazi, Hicham   +2 more
core   +2 more sources

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Stage effect of chronic kidney disease in erectile function

International Brazilian Journal of Urology
Purpose The study aims to assess the influence of the stage of chronic kidney disease and glomerular filtration rate on prevalence and degree of erectile dysfunction. Materials and Methods This transversal study, conducted from May 2013 to December 2015,
Márcio Rodrigues Costa, Viviane Campos Ponciano, Théo Rodrigues Costa, Caio Pereira Gomes, Enio Chaves de Oliveira   +4 more
doaj   +1 more source

Expert Strategies: Controversies in Management of Sinonasal Malignancies—Global Perspectives Through a Mixed Methods Approach

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Sinonasal malignancies (SNMs) are a rare group of diseases with limited high‐level evidence to guide management. Where data are currently lacking, contemporary management principles may be guided by clinical expertise and experience.
Garret Choby, Katie M. Phillips, Michael Xie, Jason R. Crossley, Vivek C. Pandrangi, Vidit M. Talati, Michael T. Chang, Jennifer E. Douglas, Mathew N. Geltzeiler, Nyall R. London Jr, Christopher R. Roxbury, John R. Craig, Zara M. Patel, Ahmad R. Sedaghat, Raj Sindwani, Bobby A. Tajudeen, Nithin D. Adappa, Neal S. Akhave, Christian S. Betz, Ricardo L. Carrau, Roy R. Casiano, Paolo Castelnuovo, Marc A. Cohen, John R. de Almeida, Marco Ferrari, Charalampos S. Floudas, Christos Georgalas, Ehab Y. Hanna, Glenn J. Hanna, Pr. Philippe Herman, Adam L. Holtzman, Jay J. Liao, John N. Lukens, Erin L. McKean, William M. Mendenhall, Piero Nicolai, Gurston G. Nyquist, Kazuhiro Omura, James N. Palmer, Jack Phan, Katharine A. Price, Mindy R. Rabinowitz, Marc R. Rosen, Nabil F. Saba, Zoukaa B. Sargi, Carl H. Snyderman, Shirley Y. Su, Raymond Tsang, Mario Turri‐Zanoni, Pr. Benjamin Verillaud, Eric W. Wang, Christopher T. Wilke, Ian J. Witterick, Tae‐Bin Won, Dan P. Zandberg, Pete S. Batra, Edward C. Kuan   +56 more
wiley   +1 more source

Investigating a patient with erectile dysfunction: Is it really necessary?

Indian Journal of Urology, 2006
The National Institute of Health defined erectile dysfunction as the persistent inability to achieve and/or to maintain an erection for a satisfactory sexual performance.
Vincenzo Mirone
doaj   +1 more source

Erectile dysfunction etiology and hormonal changes. Minireview [PDF]

, 2012
Erectile dysfunction etiology and hormonal changes ...
Orro, Helen, Kokk, Kersti
core   +1 more source

The fossil record stays silent: Confusions and conundrums for hominin pelvis evolution

The Anatomical Record, EarlyView.
Abstract The evolution of the hominin pelvis is commonly modeled as a series of stages driven largely by the requirements of bipedal locomotion, reproduction, thermoregulation, and pelvic floor muscular support. These patterns are complicated by variation in canal dimensions in relationship with different changes in overall pelvic breadths. To quantify
Helen K. Kurki, Cara M. Wall‐Scheffler
wiley   +1 more source