Results 121 to 130 of about 4,387 (238)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

open access: yesAdvanced Science, Volume 13, Issue 9, 13 February 2026.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li   +14 more
wiley   +1 more source

The effect of animacy on the agent preference: Self-paced reading evidence from Basque. [PDF]

open access: yesMem Cognit
Egurtzegi A   +9 more
europepmc   +1 more source

Amyloid‐related default mode network hyperconnectivity and longitudinal decline in network distinctiveness in preclinical Alzheimer's disease

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION We investigated stage‐specific alterations in functional connectivity (FC) of the default mode network (DMN) across the Alzheimer's disease (AD) continuum and tested whether early amyloid beta (Aβ)–related changes in within‐DMN FC (DMN‐FCwithin) predicted longitudinal alterations in DMN between‐network connectivity (DMN‐FCbetween).
Woo‐Jin Cha   +16 more
wiley   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton   +12 more
wiley   +1 more source

Element Specific Room Temperature Non‐Collinear Magnetism in the M‐Type Hexaferrite SrCo1.2Ti1.2Fe9.6O19${\rm SrCo}_{1.2}{\rm Ti}_{1.2}{\rm Fe}_{9.6}{\rm O}_{19}$

open access: yesAdvanced Physics Research, Volume 5, Issue 2, February 2026.
Non‐collinear magnetism is of high interest in the field of magnetoelectrics supplying a convenient mechanism to break inversion symmetry and thereby allowing for a spontaneous electrical polarization. Such “multiferroics of spin origin” are inherently suitable for electric field control of magnetism, offering a route toward low power ICT applications.
Ohoud Alsaqer   +7 more
wiley   +1 more source

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