Results 1 to 10 of about 8,478 (179)

Ergotamine and triptans induced medication-overuse headache: a real-world population-based comparative study from the Northern Thai headache registry [PDF]

The Journal of Headache and Pain
Background Medication-overuse headache (MOH) remains a leading cause of chronic daily headache globally. Although triptans are the predominant implicated in high-income countries, ergotamine continues to be widely used in many low- and middle-income ...
Surat Tanprawate, Kitti Thiankhaw, Watthikorn Chusilthong, Vipanee Muangchean, Sirinada Ma-imjai, Noratham Chalapati, Kanokkarn Teekaput, Chutithep Teekaput   +7 more
doaj   +2 more sources

Ergotamine enhances circadian amplitude and diurnally mitigates nitroglycerin-induced mechanical hypersensitivity [PDF]

The Journal of Headache and Pain
Background Cluster headache and migraine have a circadian timing of attacks and are linked to the trigeminovascular system. Recently the trigeminal ganglion was found to have a strong circadian rhythm, with the serotonin 2A receptor identified as a clock-
Chorong Han, Hwayoung Baek, Ji Ye Lim, Eunju Kim, Celia K. Tran, Emma Freeman, Zheng Chen, Seung-Hee Yoo, Mark J. Burish   +8 more
doaj   +2 more sources

Effects of Psilocin and Psilocybin on Human 5-HT₄ Serotonin and H₂ Histamine Receptors in Perfused Hearts of Transgenic Mice [PDF]

Pharmaceuticals
Background/Objectives: Hallucinogenic substances such as psilocybin, psilocin, ergometrine, ergotamine, and lysergic acid diethylamide (LSD) have been demonstrated to enhance the force of contraction (FOC), in part due to the phosphorylation of ...
Pauline Braekow, Joachim Neumann, Uwe Kirchhefer, Ulrich Gergs   +3 more
doaj   +2 more sources

A potentially lethal interaction: Migraine, human immunodeficiency virus and ergotism – A primary care case report [PDF]

Malaysian Family Physician
Ergotism is a rare but potentially serious condition characterised by peripheral vasospasm. Its diagnosis is challenging because the presentation varies depending on the type and location of the affected blood vessels.
Ahmad Sahli Mahzuz Ismail, Shaiful Bahari Ismail, Lili Husniati Yaacob   +2 more
doaj   +2 more sources

Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development [PDF]

International Journal of Genomics
Prostate cancer (PCa) is a major malignancy affecting men and is a significant contributor to global male mortality. Over the past decade, several new treatments for advanced PCa have been approved; however, opportunities remain for the development of ...
Md Amanat Ullah Arman, Md. Selim Reza, Muhammad Habibulla Alamin, Tasnia Akter Maya, Md. Tofazzal Hossain   +4 more
doaj   +2 more sources

First Synthesis of Ergotamine-¹³CD₃ and Ergotaminine-¹³CD₃ from Unlabeled Ergotamine [PDF]

Toxins
Ergot alkaloids (EAs) formed by Claviceps fungi are one of the most common food contaminants worldwide, affecting cereals such as rye, wheat, and barley.
Sven-Oliver Herter, Hajo Haase, Matthias Koch   +2 more
doaj   +2 more sources

In the era of monoclonal antibodies targeting the calcitonin gene-related peptide pathway, is it still necessary to stop taking excessive pain medication? [PDF]

Arquivos de Neuro-Psiquiatria
Medication-overuse headache (MOH) was first described in 1951 with ergotamine overuse. Since then, much has been studied about its risk factors, pathophysiology, prevention, and treatment. Despite this, many people still suffer from this condition.
Renata Gomes Londero
doaj   +2 more sources

Ergotamine Targets KIF5A to Facilitate Anoikis in Lung Adenocarcinoma [PDF]

The Clinical Respiratory Journal
Background Kinesin family member 5A (KIF5A) has been reported to be closely related to cancer progression. The aim of this study was to investigate the effect of KIF5A on lung adenocarcinoma (LUAD) and its potential molecular mechanisms.
Bin Bao, Xiaojun Yu, Wujun Zheng, Jiewei Sun   +3 more
doaj   +2 more sources

Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in Xenopus oocytes [PDF]

Computational and Structural Biotechnology Journal
The relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic
Sanung Eom, Minsu Pyeon, Myungmi Moon, Jeongyeon Yun, Jaehui Yang, Jihwon Yun, Hye Duck Yeom, Mee-Hyun Lee, Gihyun Lee, Junho H. Lee   +9 more
doaj   +2 more sources

Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations [PDF]

Scientific Reports
TMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. It has been found to activate SARS-CoV-2, enhance viral infection of human small-intestinal enterocytes and is overexpressed in different types of ...
Ismail Hdoufane, Mehdi Oubahmane, Youssef Habibi, Christelle Delaite, Mohammed M. Alanazi, Driss Cherqaoui   +5 more
doaj   +2 more sources