Results 11 to 20 of about 8,701 (200)

The Application of the Neuroprotective and Potential Antioxidant Effect of Ergotamine Mediated by Targeting N-Methyl-D-Aspartate Receptors

Antioxidants, 2022
(1) Background: The N-methyl-D-aspartate receptors (NMDARs) mediate fast excitatory currents leading to depolarization. Postsynaptic NMDARs are ionotropic glutamate receptors that mediate excitatory glutamate or glycine signaling in the CNS and play a ...
Shinhui Lee, Sanung Eom, Khoa V. A. Nguyen, Jiwon Lee, Youngseo Park, Hye Duck Yeom, Junho H. Lee   +6 more
doaj   +2 more sources

Ergotamine enhances circadian amplitude and diurnally mitigates nitroglycerin-induced mechanical hypersensitivity. [PDF]

J Headache Pain
Background Cluster headache and migraine have a circadian timing of attacks and are linked to the trigeminovascular system. Recently the trigeminal ganglion was found to have a strong circadian rhythm, with the serotonin 2A receptor identified as a clock-
Han C, Baek H, Lim JY, Kim E, Tran CK, Freeman E, Chen Z, Yoo SH, Burish MJ.   +8 more
europepmc   +3 more sources

Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model

Scientific Reports, 2021
The ergot alkaloid ergotamine is produced by Claviceps purpurea, a parasitic fungus that commonly infects crops and pastures of high agricultural and economic importance.
Priyanka Reddy, Delphine Vincent, Joanne Hemsworth, Vilnis Ezernieks, Kathryn Guthridge, German C. Spangenberg, Simone J. Rochfort   +6 more
doaj   +2 more sources

Effects and mechanisms of action of the ergopeptides ergotamine and ergovaline and the effects of peramine on reticulum motility of sheep. [PDF]

American Journal of Veterinary Research, 2009
OBJECTIVE To investigate effects and mechanisms of ergotamine and ergovaline and effects of peramine on reticulum motility of sheep. SAMPLE POPULATION 3 sheep with indwelling electrodes in the reticulum and samples of reticulum collected from 126 sheep
D. Poole, R. Littler, Barry L. Smith, L. Mcleay   +3 more
semanticscholar   +2 more sources

Ergotamine/Caffeine Overdose in a Female Suffering From Migraine Headache: A Case Report [PDF]

Pharmaceutical and Biomedical Research
Background: Ergotamine is a very common antimigraine and is widely used in the management of headaches such as cluster and acute migraines. However, Ergotamine poisoning is an infrequent condition, and there are very few cases reported.
Amir Hasan Farzaneh, Navid Khosravi
doaj   +2 more sources

Capillary electrophoretic determination of antimigraine formulations containing caffeine, ergotamine, paracetamol and domperidone or metoclopramide.

Journal of Chromatographic Science, 2013
A novel, fast, sensitive and specific technique using capillary electrophoresis coupled to a diode array detector has been developed for the separation and simultaneous determination of two antimigraine mixtures in tablet formulation.
M. Sultan, H. Maher, Nora Z Alzoman, Mona M. Alshehri, M. Rizk, Mona S. Elshahed, Ileana V. Olah   +6 more
semanticscholar   +2 more sources

Ischemic Colitis Secondary to Ergotamine Use: A Case Study

Case Reports in Gastroenterology, 2011
A 48-year-old woman with a history of chronic migraines, initially admitted for inpatient management of intractable migraine headaches, developed new onset abdominal pain, hypotension, and diarrhea on hospital day number ten.
Regina E. Rodman, Thomas D. Willson, Mark M. Connolly, Francis J. Podbielski   +3 more
doaj   +2 more sources

Ergot alkaloids: From witchcraft till in silico analysis. Multi-receptor analysis of ergotamine metabolites

Toxicology Reports, 2015
The term Ergot is referred to the sclerotium of ascomycetes – a protective kernel produced during resting stage of some fungi – which replaces seeds of susceptible cereals and plants intended for human and animal diet.
Luca Dellafiora, Chiara Dall’Asta, Pietro Cozzini   +2 more
doaj   +2 more sources

A potentially lethal interaction: Migraine, human immunodeficiency virus and ergotism - A primary care case report. [PDF]

Malays Fam Physician
Ergotism is a rare but potentially serious condition characterised by peripheral vasospasm. Its diagnosis is challenging because the presentation varies depending on the type and location of the affected blood vessels.
Ahmad Sahli Mahzuz I, Shaiful Bahari I, Yaacob LH.   +2 more
europepmc   +2 more sources

Ergotamine Stimulates Human 5-HT₄-Serotonin Receptors and Human H₂-Histamine Receptors in the Heart. [PDF]

Int J Mol Sci, 2023
Ergotamine (2′-methyl-5′α-benzyl-12′-hydroxy-3′,6′,18-trioxoergotaman) is a tryptamine-related alkaloid from the fungus Claviceps purpurea. Ergotamine is used to treat migraine.
Jacob H, Braekow P, Schwarz R, Höhm C, Kirchhefer U, Hofmann B, Neumann J, Gergs U.   +7 more
europepmc   +2 more sources