Drug Repurposing of Approved Drugs Elbasvir, Ledipasvir, Paritaprevir, Velpatasvir, Antrafenine and Ergotamine for Combating COVID19 [PDF]
, 2020 Pneumonia of unknown cause detected in Wuhan, China was first reported to the WHO Country Office in China on 31 December 2019. The outbreak was declared a Public Health Emergency of International Concern on 30 January 2020.
Vishal Mevada +5 more
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Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development [PDF]
International Journal of GenomicsProstate cancer (PCa) is a major malignancy affecting men and is a significant contributor to global male mortality. Over the past decade, several new treatments for advanced PCa have been approved; however, opportunities remain for the development of ...
Md Amanat Ullah Arman +4 more
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Ergotamine Targets KIF5A to Facilitate Anoikis in Lung Adenocarcinoma [PDF]
The Clinical Respiratory JournalBackground Kinesin family member 5A (KIF5A) has been reported to be closely related to cancer progression. The aim of this study was to investigate the effect of KIF5A on lung adenocarcinoma (LUAD) and its potential molecular mechanisms.
Bin Bao +3 more
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In the era of monoclonal antibodies targeting the calcitonin gene-related peptide pathway, is it still necessary to stop taking excessive pain medication? [PDF]
Arquivos de Neuro-PsiquiatriaMedication-overuse headache (MOH) was first described in 1951 with ergotamine overuse. Since then, much has been studied about its risk factors, pathophysiology, prevention, and treatment. Despite this, many people still suffer from this condition.
Renata Gomes Londero
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Identification of potent TMPRSS4 inhibitors through structural modeling and molecular dynamics simulations [PDF]
Scientific ReportsTMPRSS4, a transmembrane serine protease type II, is associated with various pathological illnesses. It has been found to activate SARS-CoV-2, enhance viral infection of human small-intestinal enterocytes and is overexpressed in different types of ...
Ismail Hdoufane +5 more
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Ischemic Colitis Secondary to Ergotamine Use: A Case Study
Case Reports in Gastroenterology, 2011 A 48-year-old woman with a history of chronic migraines, initially admitted for inpatient management of intractable migraine headaches, developed new onset abdominal pain, hypotension, and diarrhea on hospital day number ten.
Regina E. Rodman +3 more
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Molecular investigation of ergot alkaloid ergotamine's modulatory effects on glycine receptors expressed in Xenopus oocytes [PDF]
Computational and Structural Biotechnology JournalThe relationship between oxidative stress and glycine receptors is complex, involving multiple mechanisms through which reactive oxygen species can modify glycine receptor function. Understanding these interactions is essential for developing therapeutic
Sanung Eom +9 more
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TLC densitometric approach for concurrent determination of quinary mixture for treatment of migraine with appraisal to method greenness and whiteness [PDF]
Scientific ReportsA new accurate, precise thin layer chromatographic (TLC densitometric) approach was developed for the simultaneous analysis of ergotamine tartrate (ERG), phenobarbital sodium (PHEN), caffeine anhydrous (CAF), dipyrone sodium (DIP) and meprobamate (MEP ...
Marco M. Z. Sharkawi +3 more
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Identifying potential drug targets in the kinomes of two monogenean species [PDF]
HelminthologiaProtein kinases are enzymes involved in essential biological processes such as signal transduction, transcription, metabolism, and the cell cycle. Human kinases are targets for several drugs approved by the US Food and Drug Administration. Therefore, the
Caña-Bozada V. H. +4 more
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Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines [PDF]
Acta Pharmaceutica Sinica BErgopeptines or their derivatives are widely used for treating neurodegenerative and cerebrovascular diseases. The nonribosomal peptide synthetase—d-lysergyl peptide synthetase A (LPSA) determines ergopeptine formation but the detailed mechanism remains ...
Jing-Jing Chen +5 more
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