Results 21 to 30 of about 8,478 (179)

Update on medication-overuse headache and its treatment [PDF]

, 2015
OPINION STATEMENT: Medication-overuse headache-i.e., a too-frequent consumption of acute headache medications leading to increased headache frequency and reduced effectiveness of acute and preventive treatments-is a serious medical condition whose ...
Giamberardino MA, MARTELLETTI, Paolo, Mitsikostas DD   +2 more
core   +1 more source

BMC Microbiology / Rhodococcus erythropolis MTHt3 biotransforms ergopeptines to lysergic acid [PDF]

, 2015
Background: Ergopeptines are a predominant class of ergot alkaloids produced by tall fescue grass endophyte Neotyphodium coenophialum or cereal pathogen Claviceps purpurea.
Apfelthaler, Elisabeth, Kneifel, Wolfgang, Krska, Rudolf, Kunz-Vekiru, Elisavet, Moll, Wulf-Dieter, Schatzmayr, Gerd, Schwartz-Zimmermann, Heidi Elisabeth, Thamhesl, Michaela   +7 more
core   +1 more source

Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure

Frontiers in Physiology, 2014
Severely affected patients with autonomic failure require pressor agents to counteract the blood pressure fall and improve presyncopal symptoms upon standing.
Amy C Arnold, Claudia E Ramirez, Leena eChoi, Luis E Okamoto, Alfredo eGamboa, André eDiedrich, Satish R Raj, David eRobertson, Italo eBiaggioni, Cyndya Adriana Shibao   +9 more
doaj   +1 more source

Effects of ergotamine on the central nervous system using untargeted metabolomics analysis in a mouse model

Scientific Reports, 2021
The ergot alkaloid ergotamine is produced by Claviceps purpurea, a parasitic fungus that commonly infects crops and pastures of high agricultural and economic importance.
Priyanka Reddy, Delphine Vincent, Joanne Hemsworth, Vilnis Ezernieks, Kathryn Guthridge, German C. Spangenberg, Simone J. Rochfort   +6 more
doaj   +1 more source

Eletriptan in the management of acute migraine. An update on the evidence for efficacy, safety, and consistent response [PDF]

, 2016
Migraine is a multifactorial, neurological and disabling disorder, also characterized by several autonomic symptoms. Triptans, selective serotonin 5-HT1B/1D agonists, are the first-line treatment option for moderate-to-severe headache attacks.
Capi, Matilde, Curto, Martina, De Andrés, Fernando, Gentile, Giovanna, Lionetto, Luana, Martelletti, Paolo, Negro, Andrea   +6 more
core   +1 more source

In Silico Screening of Novel TMPRSS2 Inhibitors for Treatment of COVID-19

Molecules, 2022
COVID-19, a pandemic caused by the virus SARS-CoV-2, has spread globally, necessitating the search for antiviral compounds. Transmembrane protease serine 2 (TMPRSS2) is a cell surface protease that plays an essential role in SARS-CoV-2 infection ...
Shuo Wang, Xuexun Fang, Ye Wang
doaj   +1 more source

Determination of non-cytotoxic antiviral concentrations of purine and indole derivatives in vitro [PDF]

Pharmacia
Mammalian cells from lines derived from bovine embryonic trachea (EBTr) were used in the present study. After the formation of semi-confluent monolayers, one subpopulation of cells was inoculated with the vaccine avian poxvirus strain FK (fowl) and the ...
Iskra Sainova, Vera Kolyovska, Iliana Ilieva, Rumen Nikolov, Andrey Petrov, Radka Hadjiolova, Dimitrina Dimitrova-Dikanarova, Tzvetanka Markova   +7 more
doaj   +3 more sources

Simultaneous Determination of Ergot Alkaloids in Swine and Dairy Feeds Using Ultra High-Performance Liquid Chromatography-Tandem Mass Spectrometry

Toxins, 2021
Ergot alkaloids (EAs) are mycotoxins mainly produced by the fungus Claviceps purpurea. EAs are known to affect the nervous system and to be vasoconstrictors in humans and animals.
Saranya Poapolathep, Narumol Klangkaew, Zhaowei Zhang, Mario Giorgi, Antonio Francesco Logrieco, Amnart Poapolathep   +5 more
doaj   +1 more source

Triptans and CGRP blockade - impact on the cranial vasculature [PDF]

, 2017
The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide ...
Alejandro Labastida-Ramírez, Anne Luise Vollesen, Christian Lampl, Francesca Cortese, Francesca Marchese, Lanfranco Pellesi, Messoud Ashina, Michele Romoli, On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS), Silvia Benemei   +9 more
core   +3 more sources

Ergotamine-induced acute tubulo-interstitial nephritis

Saudi Journal of Kidney Diseases and Transplantation, 2013
Ergotamine has been used for the treatment of migraine for many years, and its use in adults is considered to be safe and effective. In this report, we present a 22-year-old female patient, a known case of migraine, who was on ergotamine tartrate and ...
Maryam Pakfetrat, Akbar Rasekhi, Fatemeh Eftekhari, Nahid Hashemi, Jamshid Roozbeh, Simin Torabineghad, Leila Malekmakan   +6 more
doaj   +1 more source