Results 41 to 50 of about 394,843 (294)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Influence of Buried Pipeline Leakage on the Development of Cavities in the Subgrade

Buildings, 2023
The rapid pace of urbanization has led to an increasing frequency of road collapses, posing a significant threat to urban traffic safety. Underground pipeline leakage stands out as the primary cause of such collapses.
Xianghua Chen, Wenxin Chen, Liyuan Zhao, Yekai Chen   +3 more
doaj   +1 more source

Mapping erosion-corrosion of carbon steel in oil exploration conditions : some new approaches to characterizing mechanisms and synergies [PDF]

, 2010
Erosion by solid particles in oil/water slurries is a technologically important area. In such conditions, it is necessary to distinguish between the effects of the sand, aqueous environment, and the oil.
Abdulrahmen, G.H., Stack, M.M.
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Mapping erosion-corrosion of carbon steel in oil-water solutions : Effect of velocity and applied potential [PDF]

, 2012
In this study, the combined effects of erosion and corrosion on carbon steel were investigated in three environments containing crude oil, reservoir water, and a mixture of both solutions at a range of applied potentials, velocities and impact angle. The
Abdulrahman, Ghaith, Stack, Margaret
core   +1 more source

Centrifuge Modelling of an Internal Erosion Mechanism [PDF]

Scour and Erosion, 2010
Suffusion is an internal erosion mechanism, which means the transport of fine particles within the soil due to hydraulic interflows. With the objective to characterize this mechanism and to study a scale effect presented in literature, a specific centrifuge bench is designed. Test specimens of mixture of sand and kaolinite are compacted in rigid walled
Le, van Duong, Marot, Didier, Thorel, Luc, Garnier, Josselin, Audrain, Philippe   +4 more
openaire   +3 more sources

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Experimental Erosion Flow Pattern Study of Pelton Runner Buckets Using a Non-Recirculating Test Rig

Energies
Sediment erosion of hydraulic turbines is a significant challenge in hydropower plants in mountainous regions like the European Alps, the Andes, and the Himalayan region.
Baig Mirza Umar, Zhengwei Wang, Sailesh Chitrakar, Bhola Thapa, Xingxing Huang, Ravi Poudel, Aaditya Karna   +6 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source