Results 261 to 270 of about 388,536 (334)

Cellular and molecular cross‐talk in atrial fibrillation: The role of non‐cardiomyocytes in creating an arrhythmogenic substrate

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Illustration of cellular and molecular cross‐talk in atrial fibrillation. Left: a schematic of cardiac tissue showing cardiomyocytes, fibroblasts, adipocytes, inflammatory cells and the coagulation system. Right: direct and indirect cross‐talk between different cell types, with the impact of direct cross‐talk on action potential (
Zhenyu Dong   +2 more
wiley   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí   +4 more
wiley   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera   +6 more
wiley   +1 more source

Pain Measurement in Infants and Children With and at Risk for Intellectual Disabilities

open access: yesPaediatric and Neonatal Pain, Volume 7, Issue 4, December 2025.
ABSTRACT Standards of patient care require that comprehensive pain assessments be conducted at routine intervals. Infants and children with and at risk for intellectual disabilities, who are at high risk for experiencing pain, receive significantly less representation in the literature to inform pain measurement practice.
Morgan MacNeil   +4 more
wiley   +1 more source

Targets and strategies to design soybean seed composition traits

open access: yesThe Plant Genome, Volume 18, Issue 4, December 2025.
Abstract Breeders and geneticists have put great effort into enhancing soybean seed composition and developing elite varieties with desired traits. However, diverse end‐uses and changing consumer preferences present new challenges and opportunities to develop desired compositional profiles for the market.
Ritesh Kumar   +9 more
wiley   +1 more source

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