Serum Uromodulin, a Potential Biomarker of Tubulointerstitial Damage, Correlates Well with Measured GFR and ERPF in Patients with Obstructive Nephropathy [PDF]
Medicina (Lithuania), 2022 Background and Objectives: In chronic kidney obstruction, the severity of tubulointerstitial damage correlates best with the loss of kidney function and the risk for progression to end-stage kidney disease.
Zoran Bukumiric
exaly +6 more sources
Effects of Direct Renin Blockade on Renal & Systemic Hemodynamics and on RAAS Activity, in Weight Excess and Hypertension: A Randomized Clinical Trial. [PDF]
PLoS ONE, 2017 AimThe combination of weight excess and hypertension significantly contributes to cardiovascular risk and progressive kidney damage. An unfavorable renal hemodynamic profile is thought to contribute to this increased risk and may be ameliorated by direct
A J Kwakernaak +10 more
doaj +18 more sources
Functional assessment of renal damage in children with primary vesicoureteral reflux [PDF]
Frontiers in PediatricsObjectivesTo evaluate the renal function damage in children with primary vesicoureteral reflux (VUR).MethodsA total of 226 children with VUR (65 cases with left, 39 with right, and 122 cases with bilateral VUR) were screened.
Yaju Zhu, Yufeng Li, Jing Jin, Jiajia Ni
doaj +2 more sources
Rationale and study design of a randomized controlled trial to investigate the renoprotective effect of canagliflozin assessed by test of renal hemodynamics in diabetic kidney disease (the FAGOTTO study) [PDF]
BMC Nephrology, 2023 Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are considered to have the potential to maintain renal function by correcting glomerular hypertension in patients with diabetic kidney disease (DKD).
Sawako Kato +5 more
doaj +2 more sources
EJNMMI Research, 2018 Background A method was developed to assess the kidney parameters glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) from 2-deoxy-2-[18F]fluoro-d-glucose (FDG) concentration behavior in kidneys, measured with positron emission ...
László Papp +2 more
exaly +3 more sources
Significant negative association with age and both GFR and ERPF in male and female living kidney donors [PDF]
Nephrology Dialysis Transplantation, 2006 Sir, Berg reports that glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) were unrelated to age in 62 female potential kidney donors, whereas in 60 male potential donors, GFR and ERPF were lower in older subjects [1]. They conclude that effects of ageing on the kidney are gender-related.
Gerjan Navis
exaly +3 more sources
Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome [PDF]
Nature CommunicationsThe Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome.
Hugh D. Goold +28 more
doaj +2 more sources
qTAG: an adaptable plasmid scaffold for CRISPR-based endogenous tagging [PDF]
The EMBO JournalEndogenous tagging enables the study of proteins within their native regulatory context, typically using CRISPR to insert tag sequences directly into the gene sequence.
Reuben Philip +7 more
doaj +2 more sources
Impact of Renal Stone Clearance in Patients of Chronic Kidney Disease: A Prospective Observational Study from a Tertiary Care Centre [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Varying degrees of renal insufficiency is associated with renal stone disease. The incidence of Chronic Kidney Disease (CKD) in renal stone is around 0.8 to 17.5%.
Dhananjay Selukar +3 more
doaj +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2023 The glomerular filtration rate (GFR) is important for assessing renal function and must be calculated reliably and reproducibly. This study aimed to compare the reliability and accuracy of GFR estimated with 99m-technetium diethylene-triamine ...
Shantanu Sapru +5 more
doaj +1 more source