Serum Uromodulin, a Potential Biomarker of Tubulointerstitial Damage, Correlates Well With Measured GFR and ERPF in Patients With Obstructive Nephropathy [PDF]
Medicina (Lithuania), 2022 Background and Objectives: In chronic kidney obstruction, the severity of tubulointerstitial damage correlates best with the loss of kidney function and the risk for progression to end-stage kidney disease.
Zoran Bukumirić, Romana Mijović
exaly +6 more sources
Functional assessment of renal damage in children with primary vesicoureteral reflux [PDF]
Frontiers in PediatricsObjectivesTo evaluate the renal function damage in children with primary vesicoureteral reflux (VUR).MethodsA total of 226 children with VUR (65 cases with left, 39 with right, and 122 cases with bilateral VUR) were screened.
Yaju Zhu, Yufeng Li, Jing Jin, Jiajia Ni
doaj +2 more sources
Rationale and study design of a randomized controlled trial to investigate the renoprotective effect of canagliflozin assessed by test of renal hemodynamics in diabetic kidney disease (the FAGOTTO study) [PDF]
BMC Nephrology, 2023 Background Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are considered to have the potential to maintain renal function by correcting glomerular hypertension in patients with diabetic kidney disease (DKD).
Sawako Kato +5 more
doaj +2 more sources
Uncovering the antifungal potential of Cannabidiol and Cannabidivarin [PDF]
PLoS Neglected Tropical DiseasesFungal infections pose a major threat to human health with increasing incidence of antifungal resistance globally. Despite the need for novel antifungal drugs, few are currently in clinical development.
Hue Dinh +15 more
doaj +3 more sources
Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome [PDF]
Nature CommunicationsThe Sc2.0 global consortium to design and construct a synthetic genome based on the Saccharomyces cerevisiae genome commenced in 2006, comprising 16 synthetic chromosomes and a new-to-nature tRNA neochromosome.
Hugh D. Goold +28 more
doaj +2 more sources
qTAG: an adaptable plasmid scaffold for CRISPR-based endogenous tagging [PDF]
The EMBO JournalEndogenous tagging enables the study of proteins within their native regulatory context, typically using CRISPR to insert tag sequences directly into the gene sequence.
Reuben Philip +7 more
doaj +2 more sources
Impact of Renal Stone Clearance in Patients of Chronic Kidney Disease: A Prospective Observational Study from a Tertiary Care Centre [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: Varying degrees of renal insufficiency is associated with renal stone disease. The incidence of Chronic Kidney Disease (CKD) in renal stone is around 0.8 to 17.5%.
Dhananjay Selukar +3 more
doaj +1 more source
Saudi Journal of Kidney Diseases and Transplantation, 2023 The glomerular filtration rate (GFR) is important for assessing renal function and must be calculated reliably and reproducibly. This study aimed to compare the reliability and accuracy of GFR estimated with 99m-technetium diethylene-triamine ...
Shantanu Sapru +5 more
doaj +1 more source
Fujita Medical Journal, 2020 Objectives: Renal scintigraphy is widely used to evaluate residual function of a transplanted kidney from the donor. Dynamic computed tomography (CT) imaging can evaluate both kidney morphology and regional renal function.
Yumi Kataoka +9 more
doaj +1 more source
Animals, 2020 The aim of the current study was to investigate the simultaneous measurement of plasma p-aminohippuric acid (PAH) clearance as a potential marker to assess effective renal plasma flow (eRPF) and tubular secretion (TS), and the plasma clearance of iohexol
Lenka Stroobant +7 more
doaj +1 more source