Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Comparative Error Analysis of GPT-5.2 Reasoning Modes on Performance in Postgraduate Internal Medicine Single-Best-Answer Questions. [PDF]
CureusDiyasena HK +4 more
europepmc +1 more source
Allosteric Signaling in PDZ Energetic Networks: Embedding Error Analysis. [PDF]
J Phys Chem B, 2023 Cowan BS, Beveridge DL, Thayer KM.
europepmc +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Beam-F3 error analysis and validation of Neurally-F3 equations using realistic head models. [PDF]
Sci RepPàmies-Vilà R +3 more
europepmc +1 more source
An atlas of anatomical variants of subsegmental pulmonary arteries and recognition error analysis. [PDF]
Front Oncol, 2023 Xu H +8 more
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
BOX-COX TRANSFORMATIONS AND ERROR TERM SPECIFICATION IN DEMAND MODELS [PDF]
This paper analyzes the influence of error-term specification and functional form on a quarterly demand model for beef. The Box-Cox transformation is used to generalize the functional form while the equation error term is postulated to be both ...
Blaylock, James R., Smallwood, David M.
core
Psychophysiological Outcome Responses in Human Pavlovian Fear Conditioning: A Prediction Error Analysis. [PDF]
PsychophysiologyLiu H, Linnell J, Bach DR.
europepmc +1 more source
Theoretical error analysis of spotlight-based instrument localization for retinal surgery. [PDF]
Robotica, 2023 Zhou M +7 more
europepmc +1 more source