Results 51 to 60 of about 456,084 (310)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Quantum error correction near the coding theoretical bound

open access: yesnpj Quantum Information
Recent progress in quantum computing has enabled systems with tens of reliable logical qubits, built from thousands of noisy physical qubits1.
Daiki Komoto, Kenta Kasai
doaj   +1 more source

Frequency Limited & Weighted Model Reduction Algorithm With Error Bound: Application to Discrete-Time Doubly Fed Induction Generator Based Wind Turbines for Power System

open access: yesIEEE Access, 2021
The state-space representations grant a convenient, compact, and elegant way to examine the physical systems, e.g., induction and synchronous generator-based wind turbines, with facts readily available for stability, controllability, and observability ...
Sajid Bashir   +7 more
doaj   +1 more source

Regularities and their relations to error bounds [PDF]

open access: yesMathematical Programming, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kung Fu Ng, Wei Hong Yang
openaire   +1 more source

Linear programming bounds for doubly-even self-dual codes

open access: yes, 1997
Using a variant of linear programming method we derive a new upper bound on the minimum distance d of doubly-even self-dual codes of length n. Asymptotically, for n growing, it gives d/n
Krasikov, I, Simon Litsyn, Ilia Krasikov
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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