Results 91 to 100 of about 6,085,361 (298)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Holistic Testing and Characterization of Commercial 18650 Lithium-Ion Cells

Batteries
Reduced-order electrothermal models play a key role in the design and control of lithium-ion cell stacks, calling for accurate model parameter calibration.
Nicolò Zatta, Bernardo De Cesaro, Enrico Dal Cin, Gianluca Carraro, Giovanni Cristofoli, Andrea Trovò, Andrea Lazzaretto, Massimo Guarnieri   +7 more
doaj   +1 more source

Error characterization of CO 2 vertical mixing in the atmospheric transport model WRF-VPRM

, 2011
. One of the dominant uncertainties in inverse estimates of regional CO 2 surface-atmosphere fluxes is related to model errors in vertical transport within the planetary boundary layer (PBL).
R. Kretschmer, C. Gerbig, U. Karstens, Frank-Thomas Koch   +3 more
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Error Control in Distributed Node Self-Localization

EURASIP Journal on Advances in Signal Processing, 2008
Location information of nodes in an ad hoc sensor network is essential to many tasks such as routing, cooperative sensing, and service delivery. Distributed node self-localization is lightweight and requires little communication overhead, but often ...
Ying Zhang, Juan Liu
doaj   +1 more source

Characterization and Evaluation of Rotation Accuracy of Hydrostatic Spindle under the Influence of Unbalance

Shock and Vibration, 2020
The paper studies the characterization and evaluation technology of rotation accuracy of hydrostatic spindle under the influence of unbalance. The dynamic model of the motion error of the hydrostatic spindle is established based on the dynamic parameters.
Dongju Chen, You Zhao, Jingfang Liu
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Six-Dimensional Spatial Dimension Chain Modeling via Transfer Matrix Method with Coupled Form Error Distributions

Machines
In tolerance design for complex mechanical systems, 3D dimension chain analyses are crucial for assembly accuracy. The current methods (e.g., worst-case analysis, statistical tolerance analysis) face limitations from oversimplified assumptions—treating ...
Lu Liu, Xin Jin, Huan Guo, Chaojiang Li
doaj   +1 more source