Results 81 to 90 of about 6,085,361 (298)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Uncertainty Analysis of a Test Bed for Calibrating Voltage Transformers Vs. Temperature

Sensors, 2019
The paper addresses the evaluation of the uncertainty sources of a test bed system for calibrating voltage transformers vs. temperature. In particular, the Monte Carlo method has been applied in order to evaluate the effects of the uncertainty sources in
Alessandro Mingotti, Lorenzo Peretto, Roberto Tinarelli, Abbas Ghaderi   +3 more
doaj   +1 more source

A Characterization of Prediction Errors

, 2016
Understanding prediction errors and determining how to fix them is critical to building effective predictive systems. In this paper, we delineate four types of prediction errors and demonstrate that these four types characterize all prediction errors. In addition, we describe potential remedies and tools that can be used to reduce the uncertainty when ...
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Satellite Precipitation Characterization, Error Modeling, and Error Correction Using Censored Shifted Gamma Distributions

Journal of Hydrometeorology, 2017
Abstract Satellite multisensor precipitation products (SMPPs) have a variety of potential uses but suffer from relatively poor accuracy due to systematic biases and random errors in precipitation occurrence and magnitude. The censored, shifted gamma distribution (CSGD) is used here to characterize the Tropical Rainfall Measurement ...
Daniel B, Wright, Dalia B, Kirschbaum, Soni, Yatheendradas   +2 more
openaire   +2 more sources

Characterizing Result Errors in Internet Desktop Grids [PDF]

, 2007
Desktop grids use the free resources in Intranet and Internet environments for large-scale computation and storage. While desktop grids offer a high return on investment, one critical issue is the validation of results returned by participating hosts. Several mechanisms for result validation have been previously proposed.
Derrick Kondo, Filipe Araujo, Paul Malecot, Patricio Domingues, Luis Moura Silva, Gilles Fedak, Franck Cappello   +6 more
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Statistical Analysis-Based Error Models for the Microsoft KinectTM Depth Sensor

Sensors, 2014
The stochastic error characteristics of the Kinect sensing device are presented for each axis direction. Depth (z) directional error is measured using a flat surface, and horizontal (x) and vertical (y) errors are measured using a novel 3D checkerboard ...
Benjamin Choo, Michael Landau, Michael DeVore, Peter A. Beling   +3 more
doaj   +1 more source

Characterization of Published Errors in High-Impact Oncology Journals

Current Oncology, 2009
Purpose: To assess the frequency and propagation rate of published errors in the oncology literature and to determine possible contributing factors. Methods: We reviewed 10 major oncology journals to determine variability in the online presentation of errata.
Molckovsky, A., Vickers, M.M., Tang, P.A.   +2 more
openaire   +2 more sources