Results 61 to 70 of about 739,428 (306)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Quantification and Standardized Description of Color Vision Deficiency Caused by Anomalous Trichromats—Part II: Modeling and Color Compensation

EURASIP Journal on Image and Video Processing, 2008
A color compensation scheme has been developed to enhance the perception of people with color vision deficiency (CVD) and for people suffering from anomalous trichromacy.
Seungji Yang, Yong Man Ro, Edward K. Wong, Jin-Hak Lee   +3 more
doaj   +1 more source

Frequency-Weighted Model Reduction with Applications to Structured Models [PDF]

, 2007
In this paper, a frequency-weighted extension of a recently proposed model reduction method for linear systems is presented. The method uses convex optimization and can be used both with sample data and exact models.
Murray, Richard M., Sandberg, Henrik
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Error Compensation in Insertion-region Magnets [PDF]

, 1995
In heavy ion storage rings, intra-beam scattering (IBS) between high charge state ions results in a large beam emittance during storage. The ultimate machine performance depends on achieving the highest possible magnetic field quality and alignment ...
Wei, J
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Review of Machine Learning-Based Thermal Error Modeling Methods for CNC Machine Tools

Machines
Heat source-induced thermal error is a primary element influencing the precision of CNC machine tools. A practical and economical approach to mitigating thermal errors is through thermal error compensation.
Sen Mu, Chunping Yu, Kunlong Lin, Caijiang Lu, Xi Wang, Tao Wang, Guoqiang Fu   +6 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

A Study on Error Compensation on High Precision Machine Tool System Using a 2D Laser Holographic Scale System

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Numerical error compensation is a cost-effective way to further improve the accuracy of high precision CNC machine tools. This paper discusses the major techniques for numerical error compensation on high precision machine tools. First, the high accuracy
Toru FUJIMORI, Kayoko TANIGUCHI, Chris ELLIS, Tojiro AOYAMA, Kazuo YAMAZAKI   +4 more
doaj   +1 more source

Linearly Converging Error Compensated SGD

, 2020
In this paper, we propose a unified analysis of variants of distributed SGD with arbitrary compressions and delayed updates. Our framework is general enough to cover different variants of quantized SGD, Error-Compensated SGD (EC-SGD) and SGD with delayed updates (D-SGD).
Gorbunov, Eduard, Kovalev, Dmitry, Makarenko, Dmitry, Richtárik, Peter   +3 more
openaire   +2 more sources