Results 61 to 70 of about 3,893,760 (314)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Thermal error compensation of a 5-axis machine tool using indigenous temperature sensors and CNC integrated Python code validated with a machined test piece

Precision engineering, 2020
Achieving high workpiece accuracy is the long-term goal of machine tool designers. There are many causes for workpiece inaccuracy, with thermal errors being the most common.
M. Mareš, O. Horejš, Lukáš Havlík
semanticscholar   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Review of Machine Learning-Based Thermal Error Modeling Methods for CNC Machine Tools

Machines
Heat source-induced thermal error is a primary element influencing the precision of CNC machine tools. A practical and economical approach to mitigating thermal errors is through thermal error compensation.
Sen Mu, Chunping Yu, Kunlong Lin, Caijiang Lu, Xi Wang, Tao Wang, Guoqiang Fu   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Study on Error Compensation on High Precision Machine Tool System Using a 2D Laser Holographic Scale System

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2012
Numerical error compensation is a cost-effective way to further improve the accuracy of high precision CNC machine tools. This paper discusses the major techniques for numerical error compensation on high precision machine tools. First, the high accuracy
Toru FUJIMORI, Kayoko TANIGUCHI, Chris ELLIS, Tojiro AOYAMA, Kazuo YAMAZAKI   +4 more
doaj   +1 more source

State of Health Estimation for Lithium-Ion Battery Using Empirical Degradation and Error Compensation Models

IEEE Access, 2020
State of health (SOH) estimation is always an important factor in ensuring the reliability and safety of lithium-ion batteries. In view of the shortcomings of the existing SOH estimation methods, such as non-universal, the estimation of different ...
Yuanyuan Jiang, Jie Zhang, Ling Xia, Yanbin Liu   +3 more
semanticscholar   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Geometric Error Analysis and Compensation of Rotary Axes of Five-axis Machine Tools

工程科学与技术, 2020
The position independent geometric errors (PIGEs) of the rotating axes of five-axis machine tools caused by the assembly are the key factor to determine the accuracy of the machine. Quantization analysis of the influence of PIGEs on the accuracy of error
Shijie GUO, Dongsheng ZHANG
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source