Results 111 to 120 of about 620,171 (262)

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

A dataset of publications and patents on quantum error correction (1995-2025). [PDF]

Data Brief
Barua S, Shemushee H.
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Reinforcement learning control of quantum error correction. [PDF]

Nature
Sivak V, Morvan A, Broughton M, Cortiñas RG, Bausch J, Senior AW, Neeley M, Eickbusch A, Shutty N, Beni LA, Spencer JS, Heras FJ, Edlich T, Abanin D, Abbas A, Acharya R, Aigeldinger G, Alcaraz R, Alcaraz S, Andersen TI, Ansmann M, Arute F, Arya K, Askew W, Astrakhantsev N, Atalaya J, Ballard B, Bardin JC, Bates H, Bengtsson A, Karimi MB, Bilmes A, Bilodeau S, Borjans F, Bourassa A, Bovaird J, Bowers D, Brill L, Brooks P, Browne DA, Buchea B, Buckley BB, Burger T, Burkett B, Bushnell N, Busnaina J, Cabrera A, Campero J, Chang HS, Chen S, Chiaro B, Chih LY, Cleland AY, Cochrane B, Cockrell M, Cogan J, Collins R, Conner P, Cook H, Courtney W, Crook AL, Curtin B, Damyanov M, Das S, Debroy DM, Demura S, Donohoe P, Drozdov I, Dunsworth A, Ehimhen V, Elbag AM, Ella L, Elzouka M, Enriquez D, Erickson C, Ferreira VS, Flores M, Burgos LF, Forati E, Ford J, Fowler AG, Foxen B, Fukami M, Fung AWL, Fuste L, Ganjam S, Garcia G, Garrick C, Gasca R, Gehring H, Geiger R, Genois É, Giang W, Gilboa D, Goeders JE, Gonzales EC, Gosula R, de Graaf SJ, Dau AG, Graumann D, Grebel J, Greene A, Gross JA, Guerrero J, Le Guevel L, Ha T, Habegger S, Hadick T, Hadjikhani A, Hamilton MC, Harrigan MP, Harrington SD, Hartshorn J, Heslin S, Heu P, Higgott O, Hiltermann R, Huang HY, Hucka M, Hudspeth C, Huff A, Huggins WJ, Jeffrey E, Jevons S, Jiang Z, Jin X, Joshi C, Juhas P, Kabel A, Kafri D, Kang H, Kang K, Karamlou AH, Kaufman R, Kechedzhi K, Khattar T, Khezri M, Kim S, Knaut CM, Kobrin B, Kostritsa F, Kreikebaum JM, Kudo R, Kueffler B, Kumar A, Kurilovich VD, Kutsko V, Lacroix N, Landhuis D, Lange-Dei T, Langley BW, Laptev P, Lau KM, Ledford J, Lee J, Lee K, Lester BJ, Leung W, Li L, Li WY, Li M, Lill AT, Livingston WP, Lloyd MT, Locharla A, De Lorenzo L, Lundahl D, Lunt A, Madhuk S, Maiti A, Maloney A, Mandrá S, Martin LS, Martin O, Mascot E, Das PM, Maslov D, Mathews M, Maxfield C, McClean JR, McEwen M, Meeks S, Miao KC, Minev ZK, Molavi R, Molina S, Montazeri S, Neill C, Newman M, Nguyen A, Nguyen M, Ni CH, Niu MY, Oas L, Orosco R, Ottosson K, Pagano A, Paolo AD, Peek S, Peterson D, Pizzuto A, Portoles E, Potter R, Pritchard O, Qian M, Quintana C, Ranadive A, Reagor MJ, Resnick R, Rhodes DM, Riley D, Roberts G, Rodriguez R, Ropes E, De Rose LB, Rosenberg E, Rosenfeld E, Rosenstock D, Rossi E, Roushan P, Rower DA, Salazar R, Sankaragomathi K, Sarihan MC, Satzinger KJ, Schaefer M, Schroeder S, Schurkus HF, Shahingohar A, Shearn MJ, Shorter A, Shvarts V, Small S, Smith WC, Sobel DA, Spells B, Springer S, Sterling G, Suchard J, Szasz A, Sztein A, Taylor M, Thiruraman JP, Thor D, Timucin D, Tomita E, Torres A, Torunbalci MM, Tran H, Vaishnav A, Vargas J, Vdovichev S, Vidal G, Heidweiller CV, Voorhees M, Waltman S, Waltz J, Wang SX, Ware B, Watson JD, Wei Y, Weidel T, White T, Wong K, Woo BWK, Wood CJ, Woodson M, Xing C, Yao ZJ, Yeh P, Ying B, Yoo J, Yosri N, Young E, Young G, Zalcman A, Zhang R, Zhang Y, Zhu N, Zobrist N, Zou Z, Babbush R, Bacon D, Boixo S, Chen Y, Chen Z, Devoret M, Hansen M, Hilton J, Jones C, Kelly J, Korotkov AN, Lucero E, Megrant A, Neven H, Oliver WD, Ramachandran G, Smelyanskiy V, Klimov PV.   +298 more
europepmc   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source