Results 91 to 100 of about 411,676 (266)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Does The Price Puzzle Exist in Colombia? Empirical Evidence and Policy Implications

open access: yesEcos de Economía, 2006
The price puzzle has been the focus of many studies, however, most of these studies have focused on developed economies and especially on the U.S. Owing to this tendency; we do not know if there is existence of a price puzzle in developing economies ...
Blen Solomon, Isabel Ruiz
doaj  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

FAKTOR-FAKTOR MAKROEKONOMI YANG MEMPENGARUHI PERMINTAAN UANG DI INDONESIA

open access: yesJurnal Ekonomi & Studi Pembangunan, 2015
: Money demand has an important role for monetary policy authorities in determining appropriate policies to maintain economic stability. Analysis of the demand for money is an economic analysis of the quantities required to support the measures taken by ...
Arif Widodo
doaj  

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

The construction of English grammar error correction models based on Seq2Seq model and feedback filtering mechanisms

open access: yesDiscover Artificial Intelligence
The current English grammar error correction model still has low accuracy when dealing with complex sentences and long sentence dependencies. Therefore, this study proposes a Sequence-to-Sequence (Seq2Seq) model that integrates feedback filtering ...
Danyang Zhang, Wenzheng Wei
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

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