Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The influence of error detection and error significance on neural and behavioral correlates of error processing in a complex choice task. [PDF]
Cogn Affect Behav Neurosci, 2022 Porth E, Mattes A, Stahl J.
europepmc +1 more source
Context-sensitive detection and correction of homonym errors in Japanese texts (poster session) [PDF]
, 2000 Hideya Iwasaki +3 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Impairment of speech auditory feedback error detection and motor correction in post-stroke aphasia. [PDF]
J Commun Disord, 2021 Sangtian S +3 more
europepmc +1 more source
Error detection, error correction and performance evaluation in on-line mathematical expression recognition [PDF]
, 2001 Kam-Fai Chan, Dit–Yan Yeung
openalex +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Some consequences of sensor error in a model for passive detection
, 1993 John E. Angus
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Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Efficient parallel MAP timing recovery algorithm for TDS-OFDM systems
Dianxin kexue, 2018 According to the problems of the existing timing recovery algorithm with the time-domain orthogonal frequency division multiplexing (TDS-OFDM) modulation in the wireless multimedia transmissions of 5G communications,such as slow processing speed and big ...
Yangguang LI +3 more
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