Results 31 to 40 of about 734,498 (245)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improved hybrid scrubbing scheme for spaceborne static random access memory-based field programmable gate arrays

The Journal of Engineering, 2019
With the shrinking feature sizes of static random access memory-based field programmable gate arrays (FPGAs), the occurrence probability of multiple-cell upsets (MCUs) in FPGAs continues to increase. This reduces the reliability of FPGAs.
Yue Li, Zhichun Chen, Yuyao Shen, Yongqing Wang   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A New Approach of an Error Detecting and Correcting Circuit by Arithmetic Logic Blocks [PDF]

International Journal of Electronics and Telecommunications, 2019
This paper proposes a unique method of an error detection and correction (EDAC) circuit, carried out using arithmetic logic blocks. The modified logic blocks circuit and its auxiliary components are designed with Boolean and block reduction technique ...
S. Kavitha, Fazida Hanim Hashim, Noorfazila Kamal   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Editors’ Choice—Review—Sensor-Based and Computational Methods for Error Detection and Correction in 3D Printing

ECS Sensors Plus
Additive manufacturing in the realm of 3D printing has transformed the manufacturing sector, providing unmatched freedom in design and rapid prototyping abilities.
Prateek Mehta, Mubarak A. Mujawar, Samantha Lafrance, Shonda Bernadin, Daniel Ewing, Shekhar Bhansali   +5 more
doaj   +1 more source

Multi-Task Transformer with Paradigm-Aware Embedding for Large-Scale Second German Inflectional Error Detection and Correction

Journal of Applied Science and Engineering
German poses significant challenges for second language (L2) learners in mastering inflectional rules, leading to frequent inflectional errors in written production. Existing approaches for second German inflectional error detection and correction (IEDC)
Yingying He
doaj   +1 more source

Bounding Fault-Tolerant Thresholds for Purification and Quantum Computation [PDF]

, 2008
In this paper, we place bounds on when it is impossible to purify a noisy two-qubit state if all the gates used in the purification protocol are subject to adversarial local, independent, noise.
Kay, Alastair
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Annotation Error Detection and Correction for Indonesian POS Tagging Corpus

Lontar Komputer
Linguistic Corpus is the primary material for training and evaluating machine learning models, especially for POS Tagging. However, the human-annotated corpus is not free from annotation errors.
Muhammad Alfian, Umi Laili Yuhana, Umi Laili Yuhana, Daniel Siahaan, Harum Munazharoh   +4 more
doaj   +1 more source