Results 71 to 80 of about 712,802 (346)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Selected momentum correction using induction-voltage modulator for low-flux ion beams
Physical Review Special Topics. Accelerators and Beams, 2005 A method for direct momentum correction of a selected beam particle using a controllable induction-voltage modulator is proposed for a low-flux ion beam.
Takashi Kikuchi +3 more
doaj +1 more source
Error-correcting codes for high-speed digital computers [PDF]
, 1974 Published document discusses method for correcting errors. According to this method, computer operation becomes fault-tolerant, i.e., its operation is error-free in spite of single hardware element malfunction.
Campbell, R. D.
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
PREMIER - PRobabilistic Error-correction using Markov Inference in Errored Reads [PDF]
, 2013 In this work we present a flexible, probabilistic and reference-free method of error correction for high throughput DNA sequencing data. The key is to exploit the high coverage of sequencing data and model short sequence outputs as independent ...
Dorman, Karin +4 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
Self-checking on-line testable static RAM [PDF]
, 1993 This is a fault-tolerant random access memory for use in fault-tolerant computers. It comprises a plurality of memory chips each comprising a plurality of on-line testable and correctable memory cells disposed in rows and columns for holding individually
Chau, Savio N., Rennels, David A.
core +1 more source
Purification of noisy quantum measurements
, 2010 We consider the problem of improving noisy quantum measurements by suitable preprocessing strategies making many noisy detectors equivalent to a single ideal detector. For observables pertaining to finite-dimensional systems (e.g.
D'Ariano, G. M. +2 more
core +1 more source
FEBS Open Bio, EarlyView.Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti +8 more
wiley +1 more source