Reducing bias and enhancing equity in AI-enabled precision nutrition: addressing measurement error across wearables, multiomics, and dietary data. [PDF]
Mai A +20 more
europepmc +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Cumulant-Based Approaches for Testing the Assumption of Independent Errors in Non-Gaussian Parallel and Congeneric Measures. [PDF]
Wiedermann W, Shi D.
europepmc +1 more source
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
Accuracy of VO<sub>2</sub> max Estimates From Apple Watch Series 10. [PDF]
Lambe R +8 more
europepmc +1 more source
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Modelling longitudinal and time-to-event data: a phase IV simulation study comparing R package implementations of joint models with time-varying Cox proportional-hazards regression, and the two-stage approach. [PDF]
Heege J +4 more
europepmc +1 more source
Neural signatures of model-based and model-free reinforcement learning across prefrontal cortex and striatum. [PDF]
Miranda B +5 more
europepmc +1 more source
Impact of Trait Measurement Error on Quantitative Genetic Analysis of Computer Vision-Derived Traits. [PDF]
Bi Y, Huang Y, Yu H, Morota G.
europepmc +1 more source

