Results 71 to 80 of about 1,691,919 (306)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Central limit theorems for the integrated squared error of derivative estimators [PDF]

open access: yes
A central limit theorem for the weighted integrated squared error of kernel type estimators of the first two derivatives of a nonparametric regression function is proved by using results for martingale differences and U-statistics.
Birke, Melanie
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The Comparison Between Standard Bayes Estimators of the Reliability Function of Exponential Distribution

open access: yesIbn Al-Haitham Journal for Pure and Applied Sciences, 2018
   In this paper, a Monte Carlo Simulation technique is used to compare the performance of the standard Bayes estimators of the reliability function of the one parameter exponential distribution .Three types of loss functions are adopted, namely ...
Mohammed Jamel Ali   +2 more
doaj   +1 more source

Empirical likelihood estimators for the error distribution in nonparametric regression models [PDF]

open access: yes
The aim of this paper is to show that existing estimators for the error distribution in nonparametric regression models can be improved when additional information about the distribution is included by the empirical likelihood method.
Kiwitt, Sebastian   +2 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

A New Convex Estimator Combining Ridge and Ordinary Least Squares Estimators [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة
In the presence of high correlation between the independent variables in the linear regression model, which is known as the multicollinearity problem, the ordinary least squares estimator produce large variations in the sample.
Karam Al-janabi, Mustafa Alheety
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Performance Evaluations of Gaussian Spatial Data Classifiers Based on Hybrid Actual Error Rate Estimators

open access: yesAustrian Journal of Statistics, 2020
Discrimination and classification of spatial data has been widely mentioned in the scientific literature, but lacks full mathematical treatment and easily available algorithms and software.
Kestutis Ducinskas, Lina Dreiziene
doaj   +1 more source

An empirical evaluation of small area estimators [PDF]

open access: yes
This paper investigates the comparative performance of five small area estimators. We use Monte Carlo simulation in the context of both theoretical and empirical populations.
Àlex Costa, Eva Ventura, Albert Satorra
core  

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