Results 91 to 100 of about 1,693,101 (265)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The inverse of the error function [PDF]
Pacific Journal of Mathematics, 1963 openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Finite Representations of the Wright Function
Fractal and FractionalThe two-parameter Wright special function is an interesting mathematical object that arises in the theory of the space and time-fractional diffusion equations.
Dimiter Prodanov
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
АППРОКСИМАЦИЯ СИЛЫ СОПРОТИВЛЕНИЯ ВОЗДУХА ДВИЖЕНИЮ СНАРЯДОВ АНАЛИТИЧЕСКИМИ ФУНКЦИЯМИ
Sučasnì Informacìjnì Tehnologìï u Sferì Bezpeki ta Oboroni, 2015 В статтье проводится выбор и обоснование аналитических функций, которые используются для описания силы сопротивления воздуха. Рассматриваются характерные участки и особенности изменения функций сопротивления воздуха в зависимосты от скорости полета ...
Volodymir I. Grabchac +2 more
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Existence and uniqueness of the p-generalized modified error function
Electronic Journal of Differential Equations, 2020 In this article, we define a p-generalized modified error function as the solution to a non-linear ordinary differential equation of second order, with a Robin type boundary condition at x=0.
Julieta Bollati +3 more
doaj
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source