Results 1 to 10 of about 18,006 (114)

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

open access: yesArthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram   +25 more
wiley   +1 more source

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

open access: yesAdvanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim   +12 more
wiley   +1 more source

Improving Post‐Fall Assessment Documentation in Older Inpatients Using a Structured Falls Proforma: A Retrospective Cohort Study

open access: yesAGING MEDICINE, EarlyView.
Falls among hospital inpatients are associated with significant morbidity and require comprehensive post‐fall assessment. This retrospective cohort study evaluated documentation completeness following inpatient falls in older adults and compared assessments completed using a structured Falls Proforma with standard documentation methods.
Ella V. Brockwell‐Mole   +3 more
wiley   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

open access: yesThe Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson   +6 more
wiley   +1 more source

Tracing the evolutionary history of the morpho‐anatomy of baculum in primates

open access: yesThe Anatomical Record, EarlyView.
Abstract Animal morphology reflects both evolutionary history and present‐day adaptation. Male mammal copulatory structures such as the baculum (penile bone) are ideal for studying these processes because of their complexity and high interspecific variability. In primates, however, research has focused mostly on baculum length.
Federica Spani   +3 more
wiley   +1 more source

Neurometabolite abnormalities and associations with epilepsy duration and cognition in patients with idiopathic generalized epilepsies

open access: yesEpilepsia Open, EarlyView.
Abstract Objective This study investigated whether idiopathic generalized epilepsies (IGEs) are associated with neuroinflammation by measuring neurometabolite levels and brain temperature using whole‐brain magnetic resonance spectroscopy imaging (MRSI).
Yun Lien   +11 more
wiley   +1 more source

Trends and indications for cesarean section in the ORIGINS birth cohort

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Cesarean section (CS) rates have increased substantially in Australia, with particularly high use observed in private maternity care and for pre‐labor CS. The aim of the present study was to describe the CS rates and the clinical indications for pre‐labor CS in the ORIGINS birth cohort.
Kristjana Einarsdottir   +6 more
wiley   +1 more source

Therapeutic orphans no more: Revisiting the ethical justification for excluding pregnant women from pharmaceutical clinical trials

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract For six decades, pregnant women have been routinely excluded from pharmaceutical clinical trials, a practice rooted in a protectionist ethic that emerged after the thalidomide tragedy. This narrative review examines whether that exclusion remains ethically justifiable, drawing on the obstetric, pharmacological, and bioethical literature ...
Camila Kruger Cabar   +1 more
wiley   +1 more source

Lessons learned from pregnant women's experiences with COVID‐19 vaccination in Brazil: A qualitative study

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To explore pregnant women's perceptions of COVID‐19 vaccination and factors influencing their decision making. Methods This qualitative study, part of a multinational project led by WHO and Johns Hopkins University, was conducted in Brazil between August and December 2023.
Bruna Maudonnet   +18 more
wiley   +1 more source

Radiography Interns' and Recent Graduates' Self‐Perceived Professional Competency Development at Two Saudi Universities: A Cross‐Sectional Study

open access: yesJournal of Medical Radiation Sciences, EarlyView.
This cross‐sectional study explored radiography interns' and recent graduates' perceptions of professional competency development at two Saudi universities. Positive perceptions were reported across most domains, while medico‐legal and ethical knowledge and identification of significant findings were identified as areas for targeted curricular and ...
Ahmad Subahi   +6 more
wiley   +1 more source

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