Results 71 to 80 of about 60,163 (246)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Energy Risk Analysis With Dynamic Amplitude Estimation and Piecewise Approximate Quantum Compiling

IEEE Transactions on Quantum Engineering
In this article, we generalize the approximate quantum compiling algorithm into a new method for cnot-depth reduction, which is apt to process wide target quantum circuits.
Kumar Ghosh, Kavitha Yogaraj, Gabriele Agliardi, Piergiacomo Sabino, Fernandez-Campoamor Marina, Bernabe-Moreno Juan, Giorgio Cortiana, Omar Shehab, Corey O'Meara   +8 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Unified approach to data-driven quantum error mitigation

Physical Review Research, 2021
Achieving near-term quantum advantage will require effective methods for mitigating hardware noise. Data-driven approaches to error mitigation are promising, with popular examples including zero-noise extrapolation (ZNE) and Clifford data regression (CDR)
Angus Lowe, Max Hunter Gordon, Piotr Czarnik, Andrew Arrasmith, Patrick J. Coles, Lukasz Cincio   +5 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Quantum trajectory approach to error mitigation

Physical Review A
Quantum error mitigation (EM) is a collection of strategies to reduce errors on noisy intermediate scale quantum (NISQ) devices on which proper quantum error correction is not feasible. One of such strategies entails implementing the inverse of a known noise map of an environment by using a set of completely positive maps weighted by a quasiprobability
Brecht I. C. Donvil, Rochus Lechler, Joachim Ankerhold, Paolo Muratore-Ginanneschi   +3 more
openaire   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Quantum Error Mitigated Classical Shadows

PRX Quantum
Classical shadows enable us to learn many properties of a quantum state ρ with very few measurements. However, near-term and early fault-tolerant quantum computers will only be able to prepare noisy quantum states ρ and it is thus a considerable challenge to efficiently learn properties of an ideal, noise-free state ρid.
Hamza Jnane, Jonathan Steinberg, Zhenyu Cai, H. Chau Nguyen, Bálint Koczor   +4 more
openaire   +4 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source