Results 51 to 60 of about 814,507 (284)

Quantification of Intrinsically Disordered Proteins: A Problem Not Fully Appreciated

Frontiers in Molecular Biosciences, 2018
Protein quantification is essential in a great variety of biochemical assays, yet the inherent systematic errors associated with the concentration determination of intrinsically disordered proteins (IDPs) using classical methods are hardly appreciated ...
Sara Contreras-Martos, Sara Contreras-Martos, Hung H. Nguyen, Hung H. Nguyen, Phuong N. Nguyen, Phuong N. Nguyen, Nevena Hristozova, Nevena Hristozova, Mauricio Macossay-Castillo, Mauricio Macossay-Castillo, Denes Kovacs, Denes Kovacs, Angela Bekesi, Angela Bekesi, Jesper S. Oemig, Jesper S. Oemig, Dominique Maes, Kris Pauwels, Kris Pauwels, Peter Tompa, Peter Tompa, Peter Tompa, Pierre Lebrun, Pierre Lebrun   +23 more
doaj   +1 more source

Equivalence of Equilibrium Propagation and Recurrent Backpropagation

, 2018
Recurrent Backpropagation and Equilibrium Propagation are supervised learning algorithms for fixed point recurrent neural networks which differ in their second phase.
Bengio, Yoshua, Scellier, Benjamin
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Determining the In Situ Apparent Thermal Diffusivity of a Sandy Soil

Revista Brasileira de Ciência do Solo, 2018
: The thermal wave amplitude method is used to determine soil thermal diffusivity in situ for a sandy soil in Mexico (Coatzacoalcos, Veracruz). Soil diurnal temperature fluctuations were measured from depths of 0.05 to 0.65 m, in 0.01 m increments ...
Oscar Fernando Silva Aguilar, Jorge Alberto Andaverde Arredondo, Beatris Adriana Escobedo Trujillo, Artemio Jesús Benitez Fundora   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

''LAB Fit ajuste de curvas'': um software em português para tratamento de dados experimentais

Revista Brasileira de Ensino de Física
Este artigo visa a comunicar o desenvolvimento de um software para tratamento de dados experimentais, denominado LAB Fit. Na verdade, trata-se de um pacote de programas envolvendo ajuste de curvas, gráficos 2D e 3D, estatística básica, propagação de ...
Wilton Pereira da Silva, Cleide M.D.P.S. e Silva, Cláudio G.B. Cavalcanti, Diogo D.P.S. e Silva, Ivomar B. Soares, João A.S. Oliveira, Cleiton D.P.S. e Silva   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Performance analysis of a low-complexity nonorthogonal multiple access scheme in visible light communication downlinks using pulse modulations

Intelligent and Converged Networks, 2021
Although Successive Interference Cancellation (SIC) decoding is widely adopted in Nonorthogonal Multiple Access (NOMA) schemes for the recovery of user data at acceptable complexity, the imperfect SIC would cause Error Propagation (EP), which can ...
Jian Song, Tian Cao, Hongming Zhang
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source