Results 51 to 60 of about 2,491,078 (295)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
GCB Bioenergy, 2016 It is commonly recognized that large uncertainties exist in modelled biofuel‐induced indirect land‐use change, but until now, spatially explicit quantification of such uncertainties by means of error propagation modelling has never been performed.
Judith A. Verstegen +5 more
doaj +1 more source
Two adjustments of the second levelling of Finland by using nonconventional weights
Journal of Geodetic Science, 2023 Despite being in use for more than 150 years, the error accumulation in precise levelling has not yet been completely clarified. It is believed that the error accumulation in this method is proportional to the square root of the levelling length.
Cvetkov Vasil
doaj +1 more source
Error propagation in the rocket grenade experiment [PDF]
, 1968 Error propagation in rocket-grenade ...
Ramsdale, D. J.
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
A General Euler Angle Error Model of Strapdown Inertial Navigation Systems
Applied Sciences, 2018 Attitude error models play an important role in analyzing the characteristics of navigation error propagation for the design and operation of strapdown inertial navigation systems (SINS).
Jianli Li, Pengfei Dang, Yiqi Li, Bin Gu
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Assessment of Measurement Uncertainty in Optical Marker Tracking of High-Speed Motion
Proceedings, 2020 Optical marker tracking is used in research environments to understand the dynamics of moving objects of interest. Due to the complexity of the systems and the wide field of applications, there is no simple method to assess system accuracy.
Paul Lückemann +4 more
doaj +1 more source