Results 61 to 70 of about 1,016,543 (243)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Comparative Analysis of SEC DED, EVEN-ODD, and Pyramid Codes for Distributed Storage Systems: A MATLAB-Based Study [PDF]
ITM Web of ConferencesThis study presents a comparative analysis of three erasure coding schemes—Single Error Correction Double Error Detection (SEC DED), EVEN-ODD, and Pyramid codes—within distributed storage systems, utilizing MATLAB for simulation.
Huang Shouhan
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Exploring the Roles of In-Network Caching in ICN
Dianxin kexue, 2014 The universal in-network caching, as a prominent feature of information centric networking（ICN）, plays important roles in the demonstration of ICN's advantages over other architectures. But so far, many people still have different perception of it.
Xiaoyan Hu, Jian Gong
doaj
Comment on "Optimum Quantum Error Recovery using Semidefinite Programming" [PDF]
, 2006 In a recent paper ([1]=quant-ph/0606035) it is shown how the optimal recovery operation in an error correction scheme can be considered as a semidefinite program.
Audenaert, K. +2 more
core +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Colloquium Humanarum, 2015 The aim of this paper is to present and analyze the vision that mathematics teachers of Intensive Recovery classes have about the mistakes of their students. Data were collected in semistructured interviews with such teachers, held in December 2012 and
Ana Cristina da Silva Ambrosio
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SEDAR: Soft Error Detection and Automatic Recovery in High Performance Computing Systems
Journal of Computer Science and Technology, 2020 Reliability and fault tolerance have become aspects of growing relevance in the field of HPC, due to the increased probability that faults of different kinds will occur in these systems.
Diego Montezanti
doaj +1 more source