Results 41 to 50 of about 1,529,727 (337)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Fault-tolerant and finite-error localization for point emitters within the diffraction limit

, 2016
We implement an estimator for determining the separation between two incoherent point sources. This estimator relies on image inversion interferometry and when used with the appropriate data analytics, it yields an estimate of the separation with finite ...
Bettens, Nair, Pearlman, Rayleigh, Sparrow   +4 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Self testing and repairing computer - A concept [PDF]

, 1970
STAR computer has five redundant modular function units, fixed store, arithmetic, memory, input, and output. Each unit is connected to a diagnostic control unit, each is coded for error detection and error correction.
Avizienis, A. A.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Modeling of rain attenuation and site diversity predictions for tropical regions [PDF]

Annales Geophysicae, 2015
Presented in this paper is an empirical model for long-term rain attenuation prediction and statistical prediction of site diversity gain on a slant path.
F. A. Semire, F. A. Semire, R. Mohd-Mokhtar, W. Ismail, N. Mohamad, J. S. Mandeep   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Opto-Mechatronic–Electrical Synergistic Capacitive Sensor for High-Resolution Micro-Displacement Measurement Targeting Cost-Sensitive Applications

Applied Sciences
To address the limitations of optical interferometry (strict environmental requirements, high cost) and piezoelectric methods (hysteresis, creep) in micro-displacement measurement, this study proposes a collaborative measurement approach based on the ...
Yuling Yang, Xiyao Liu, Qisheng Wu, Xiwei Zhou, Yulin Yang, Wei Li, Ye Tao, Weiyu Liu   +7 more
doaj   +1 more source

Covariance Estimation in High Dimensions via Kronecker Product Expansions [PDF]

, 2013
This paper presents a new method for estimating high dimensional covariance matrices. The method, permuted rank-penalized least-squares (PRLS), is based on a Kronecker product series expansion of the true covariance matrix. Assuming an i.i.d.
Alfred O. Hero Iii, Student Member, Theodoros Tsiligkaridis   +2 more
core   +1 more source