Results 231 to 240 of about 2,293,164 (298)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Medication administration errors in a Norwegian ambulance service: a quasi-experimental study on the impact of a team training program. [PDF]

Scand J Trauma Resusc Emerg Med
Myhr K, Ballangrud R, Porthun J, Sollid SJM, Vifladt A.   +4 more
europepmc   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Application of machine learning models in pharmaceutical engineering for prediction of pharmaceuticals solubility in supercritical solvent: study on phenytoin solubility. [PDF]

Front Chem
Yu S, Chen Y, Qiang W.
europepmc   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Environmental monitoring and enterprise reduction of pollution and carbon emission: a micro-level examination based on energy scale and intensity effects. [PDF]

Carbon Balance Manag
Zhang Y, Shi Y, Li X, Wang H.
europepmc   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Inverse probability weighted estimation of dynamic treatment regimen means in sequential multiple assignment randomised trials with missing data: a simulation study. [PDF]

Trials
Xu J, Mahar RK, Lee KJ, De Silva AP, Simpson JA.   +4 more
europepmc   +1 more source

Types and frequency of preanalytical errors occurring in the hematology laboratory at Debre Tabor comprehensive specialized hospital, North Central, Ethiopia, 2025. [PDF]

Sci Rep
Berhan A, Sharew B, Almaw A, Abeje G, Tekalign N, Damtie S, Legese B, Sisay T, Tegegne D, Worku S, Erkihun M, Getie B, Assefa A, Fentie A, Shimelis Feyisa M, Kiros T, Tiruneh T, Malede B, Malkamu B.   +18 more
europepmc   +1 more source