Results 41 to 50 of about 12,709 (160)

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non‐Clinical Evidence, and Regulatory Science

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 7, July 2026.
Abstract Pediatric oncology drug development remains uniquely challenging due to the rarity and biological heterogeneity of childhood cancers, ethical considerations in trial conduct, and the limited feasibility of large, randomized studies. Despite these barriers, recent years have seen a notable acceleration in the approval of oncology therapies for ...
Ya‐Feng Wen   +9 more
wiley   +1 more source

Erwinia chrysanthemi: pectolytic bacterium causing soft rot outbreaks of arracacha in Brazil Erwinia chrysanthemi: bactéria pectolítica envolvida na "mela" da mandioquinha-salsa no Brasil

open access: yesPesquisa Agropecuária Brasileira, 2006
The objetive of this work was to identify the pectolytic bacteria associated with soft rot of arracacha roots in Brazil. From 1998 to 2001, 227 isolates of Erwinia spp.
Gilmar Paulo Henz   +2 more
doaj   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

open access: yesPediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack   +39 more
wiley   +1 more source

Iron Regulation and Pathogenicity in Erwinia chrysanthemi 3937: Role of the Fur Repressor Protein

open access: yesMolecular Plant-Microbe Interactions, 1999
Low iron availability is a triggering signal for coordinated expression of the genes encoding pectate lyases PelB, PelC, PelD, and PelE, and chrysobactin iron transport functions, which are two main determinants of phytopathogenicity of the Erwinia ...
Thierry Franza   +2 more
doaj   +1 more source

Functional Characterisation of the Quorum‐Sensing Regulator ExpREcz in Modulation of Dickeya oryzae Motility and Virulence

open access: yesMolecular Plant Pathology, Volume 27, Issue 6, June 2026.
In the absence of OHHL synthase ExpIEcz, ExpREcz represses self‐expression via EDDR region and regulates Dickeya oryzae virulence traits. OHHL synthesised via ExpIEcz abolishes ExpREcz function but promotes OHHL production and D. oryzae virulence.
Zhibin Liang   +8 more
wiley   +1 more source

Effects of Plant Extracts and Commercial Bactericides on Erwinia Chrysanthemi Rhizome Rot Bacteria in Banana Plants

open access: yes, 2019
Isolation of Erwinia chrysanthemi rhizome rot bacteria from infected rhizome of banana plants in Twentay Township, Yangon Region was conducted in Microbiology Laboratory, Department of Botany, University of Yangon.
Sithu Aung Min, Ko Tin
core   +1 more source

The PecT Repressor Coregulates Synthesis of Exopolysaccharides and Virulence Factors in Erwinia chrysanthemi

open access: yesMolecular Plant-Microbe Interactions, 1999
Erwinia chrysanthemi 3937 synthesizes an exopolysaccharide (EPS) composed of rhamnose, galactose, and galacturonic acid. Fourteen transcriptional fusions in genes required for EPS synthesis, named eps, were obtained by Tn5-B21 mutagenesis. Eleven of them
Guy Condemine   +3 more
doaj   +1 more source

Construction and Damage Analysis of a Three‐Factor Collision Model for Potato‐Soil‐Pole

open access: yesFood Science &Nutrition, Volume 14, Issue 4, April 2026.
In this study, the potato‐soil‐pole three‐factor collision model was constructed with the potato‐soil ratio, impact velocity and impact object as the core factors, and a new coupled pole was designed to alleviate the impact damage. The potato‐soil finite element model was constructed by reverse engineering, and the deviation of the traditional ...
Qiang Guo   +4 more
wiley   +1 more source

Chemical Composition and Antibacterial Activity of Essential oil from

open access: yesNatural Product Communications, 2011
The composition of steam volatile oil from aerial parts of Salvia mukerjeei Bennet & Raizada (Lamiaceae) was analyzed by capillary GC and GCMS. The oil was rich in sesquiterpene hydrocarbons (67.3%). Among 71 identified constituents representing 91.7% of
Lalit Mohan   +3 more
doaj   +1 more source

The Erwinia chrysanthemi EC16 hrp/hrc Gene Cluster Encodes an Active Hrp Type III Secretion System That Is Flanked by Virulence Genes Functionally Unrelated to the Hrp System

open access: yesMolecular Plant-Microbe Interactions, 2004
Erwinia chrysanthemi is a host-promiscuous plant pathogen that possesses a type III secretion system (TTSS) similar to that of the host-specific pathogens E. amylovora and Pseudomonas syringae. The regions flanking the TTSS-encoding hrp/hrc gene clusters
Clemencia M. Rojas   +5 more
doaj   +1 more source

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