Results 91 to 100 of about 136,830 (332)

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis [PDF]

, 2009
Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene
De Keyser, Filip, De Vos, Martine, Elewaut, Dirk, Jacques, Peggy, Kruithof, Elli, Melis, Lode, Mielants, Herman, VANDOOREN, BERNARD, Verbruggen, August   +8 more
core   +1 more source

Haemato-biochemical study of free ranging gaur

Indian Journal of Animal Sciences, 2014
To support the health monitoring and care for the endangered gaur species, 18 apparently healthy, free-ranging gaurs (Bos gaurus gaurus) of either sex were immobilized with etorphine HCl and azaperone. The haematological values, viz.
A B SHRIVASTAV, K P SINGH, P NIGAM, K SANKAR, H R JOSHI, N RAJPUT, A ROKDE, B NAVANITHAN, S AGRAWAL, J S CHAUHAN   +9 more
doaj   +1 more source

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration

Advanced Functional Materials, EarlyView.
Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong, Ji‐Young Yoon, Junyong Ahn, Byunghak Lee, Sung‐Min Park, Jae‐Heon Kim, Buuvee Bayarkhangai, Yu Jin Kim, Sak Lee, Jonathan C. Knowles, Moon‐Young Kim, DongJun Lee, Sang‐Hoon Rhee, Hae‐Hyoung Lee, Hae‐Won Kim, Jung‐Hwan Lee   +15 more
wiley   +1 more source

Impact of chronic inflammation, assessed by hs-CRP, on the association between red cell distribution width and arterial cardiovascular disease: the Tromso Study [PDF]

, 1985
Red cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear.
Lappegard, Jostein, Ellingsen, Trygve S., Hindberg, Kristian, Mathiesen, Ellisiv Bøgeberg, Njolstad, Inger, Wilsgaard, Tom, Loechen, Maja-Lisa, Braekkan, Sigrid Kufaas, Hansen, John-Bjarne   +8 more
core   +5 more sources

Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells

Advanced Functional Materials, EarlyView.
Two populations of protocells consisting of giant unilamellar vesicles containing active species and distinct artificial organelles are competent of collective behavior by mimicking production, intercellular communication, and detection of the bioinspired signal molecule lactate. Enzymatic cascade reactions within artificial organelles demonstrate that
Arianna Balestri, Xinan Huang, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +4 more
wiley   +1 more source

Vitamin D Status and its Association with Morbidity including Wasting and Opportunistic Illnesses in HIV-Infected Women in Tanzania. [PDF]

, 2011
Vitamin D has a potential role in preventing HIV-related complications, based on its extensive involvement in immune and metabolic function, including preventing osteoporosis and premature cardiovascular disease.
Adeyemi OM, Chlebowski RT, Cox D, Diggle P, Donna Spiegelman, Eduardo Villamor, Edward L. Giovannucci, Ellen Hertzmark, Ferdinand M. Mugusi, Finkelstein JL, Gernard I. Msamanga, Guenter P, Hsu JW, James WP, Julia L. Finkelstein, Miettinen O, Saurabh Mehta, Stroder J, Wafaie W. Fawzi, WHO   +19 more
core   +2 more sources

COMPARATIVE CLINICAL PATHOLOGY OF JOHNIN AND TUBERCULIN REACTORS OF BOVINES [PDF]

Journal of Veterinary and Animal Sciences, 2008
Comparative intradermal test was done in an organised dairy farm to detect Johnin and Tuberculin positive reactors. Hematological and biochemical parameters of the reactors were compared with healthy animals.
P. C. Sij, K. Vijayakumar, P. V. Tresamol, M. R. Saseendranath   +3 more
doaj  

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Acquired Elliptocytosis as a Manifestation of Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia. [PDF]

, 2017
Acquired elliptocytosis is a known but rarely described abnormality in the myelodysplastic syndromes (MDS). Here we report the case of an elderly male who was admitted to the hospital with chest pain, dyspnea, and fatigue and was found to be anemic with ...
Dwyre, Denis M, Jonas, Brian A, Kjelland, Jacob D   +2 more
core   +2 more sources